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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei109 – 110Important for bifunctional activityUniRule annotation2
Binding sitei112dCTPUniRule annotation1
Active sitei122Proton donor/acceptorUniRule annotation1
Binding sitei141dCTPUniRule annotation1
Binding sitei155dCTPUniRule annotation1
Binding sitei162dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi95 – 100dCTP bindingUniRule annotation6
Nucleotide bindingi120 – 122dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciHSP380749:G1GCJ-571-MONOMER
UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:HY04AAS1_0561
OrganismiHydrogenobaculum sp. (strain Y04AAS1)
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
Proteomesi
  • UP000001872 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000964331 – 177dCTP deaminase, dUMP-formingAdd BLAST177

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi380749.HY04AAS1_0561

Structurei

3D structure databases

ProteinModelPortaliB4U7Y7
SMRiB4U7Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiGWIDAGF
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

B4U7Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDKTILD YIKSSKIIVE PFDESSLQCS SLDLRLSNSI AFYEELDIID
60 70 80 90 100
IKSPIQAKTV TFEEYFIINP GEFLLASTME YIKLPEFITA FVEGRSSLGR
110 120 130 140 150
LGLFIENAGW VDAGFEGQIT LELYNANKYP IKLYKGMRIC QLVFAKLDEI
160 170
PSKVYRGKYL CQKGATPSKI FMDFDKK
Length:177
Mass (Da):20,186
Last modified:September 23, 2008 - v1
Checksum:iF67E0B41B8B0CB93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA Translation: ACG57248.1
RefSeqiWP_012513604.1, NC_011126.1

Genome annotation databases

EnsemblBacteriaiACG57248; ACG57248; HY04AAS1_0561
KEGGihya:HY04AAS1_0561

Similar proteinsi

Entry informationi

Entry nameiDCDB_HYDS0
AccessioniPrimary (citable) accession number: B4U7Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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