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B4U6R7

- PNP_HYDS0

UniProt

B4U6R7 - PNP_HYDS0

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi482 – 4821MagnesiumUniRule annotation
    Metal bindingi488 – 4881MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciHSP380749:GH30-152-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:HY04AAS1_0143
    OrganismiHydrogenobaculum sp. (strain Y04AAS1)
    Taxonomic identifieri380749 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
    ProteomesiUP000001872: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 703703Polyribonucleotide nucleotidyltransferasePRO_1000147923Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi380749.HY04AAS1_0143.

    Structurei

    3D structure databases

    ProteinModelPortaliB4U6R7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini549 – 60759KHUniRule annotationAdd
    BLAST
    Domaini617 – 67963S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4U6R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVKAEIGNQ DPIYIEANKY AHQADSSILI SQGGTKVLVT VCVSEEPLCG    50
    IDFAPLSVDY RERSFAWGKI PGGFIKREGK PTDREVLISR VIDRPLRPLM 100
    PKGFLNEVVV TCLTLSADDK YDPDVLAITG ASAALVSSSV PFEGPIAGMR 150
    VCRVNGEFII NPTYEQRKNS DMDIVMALSK DAIVMVEGGA KEVEESVLLD 200
    ALFFGLEKGQ TLIKAQEELV DSLKPEKKPI GHIGLSDDMA NKLKEIASSK 250
    ILEAFSIEDK KERSKALKDV YAQAMQKLGI SKEQEFDFLV SFKDLESQLM 300
    REQILKYKKR IDGRKETDIR PITIEMHPLE RPHGSAVFTR GQTQALATVT 350
    LAPKDEAQLV ETIFEGETFK RFMLHYNFPP FSTGEARPWG PPRRREIGHG 400
    ALAERALEPL LAKEEDFPYI IRVVSDILES NGSSSMATVC AGSLALFDAG 450
    VPMKKHVAGI AMGLIKDGDN FVILTDILGD EDHLGDMDFK VAGTRDGVTS 500
    VQMDIKIKGL SKDIMIKALN QAKEARMFIL DKLYEAIPEP NKEVSKYAPK 550
    AQVMKIPEDK VGLVIGPAGK NIKYIKEQFG ASVWIDGANA YINAPTIEAV 600
    NKAADFINSL IQEVEVGGVY EGKVIRVENY GLFVEVLPGK VGLLHASAMT 650
    EKPTINVGDT IKVKVMAIDE QNRLNLCSPD YQKPENQERP RKEQLNRKPH 700
    HRK 703
    Length:703
    Mass (Da):77,809
    Last modified:September 23, 2008 - v1
    Checksum:i506DDC900A1E0BBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG56835.1.
    RefSeqiWP_012513192.1. NC_011126.1.
    YP_002120813.1. NC_011126.1.

    Genome annotation databases

    EnsemblBacteriaiACG56835; ACG56835; HY04AAS1_0143.
    GeneIDi6742930.
    KEGGihya:HY04AAS1_0143.
    PATRICi22134910. VBIHydSp64203_0141.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG56835.1 .
    RefSeqi WP_012513192.1. NC_011126.1.
    YP_002120813.1. NC_011126.1.

    3D structure databases

    ProteinModelPortali B4U6R7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380749.HY04AAS1_0143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG56835 ; ACG56835 ; HY04AAS1_0143 .
    GeneIDi 6742930.
    KEGGi hya:HY04AAS1_0143.
    PATRICi 22134910. VBIHydSp64203_0141.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci HSP380749:GH30-152-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y04AAS1.

    Entry informationi

    Entry nameiPNP_HYDS0
    AccessioniPrimary (citable) accession number: B4U6R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3