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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi482MagnesiumUniRule annotation1
Metal bindingi488MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:HY04AAS1_0143
OrganismiHydrogenobaculum sp. (strain Y04AAS1)
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
Proteomesi
  • UP000001872 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479231 – 703Polyribonucleotide nucleotidyltransferaseAdd BLAST703

Interactioni

Protein-protein interaction databases

STRINGi380749.HY04AAS1_0143.

Structurei

3D structure databases

ProteinModelPortaliB4U6R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini549 – 607KHUniRule annotationAdd BLAST59
Domaini617 – 679S1 motifUniRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U6R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVKAEIGNQ DPIYIEANKY AHQADSSILI SQGGTKVLVT VCVSEEPLCG
60 70 80 90 100
IDFAPLSVDY RERSFAWGKI PGGFIKREGK PTDREVLISR VIDRPLRPLM
110 120 130 140 150
PKGFLNEVVV TCLTLSADDK YDPDVLAITG ASAALVSSSV PFEGPIAGMR
160 170 180 190 200
VCRVNGEFII NPTYEQRKNS DMDIVMALSK DAIVMVEGGA KEVEESVLLD
210 220 230 240 250
ALFFGLEKGQ TLIKAQEELV DSLKPEKKPI GHIGLSDDMA NKLKEIASSK
260 270 280 290 300
ILEAFSIEDK KERSKALKDV YAQAMQKLGI SKEQEFDFLV SFKDLESQLM
310 320 330 340 350
REQILKYKKR IDGRKETDIR PITIEMHPLE RPHGSAVFTR GQTQALATVT
360 370 380 390 400
LAPKDEAQLV ETIFEGETFK RFMLHYNFPP FSTGEARPWG PPRRREIGHG
410 420 430 440 450
ALAERALEPL LAKEEDFPYI IRVVSDILES NGSSSMATVC AGSLALFDAG
460 470 480 490 500
VPMKKHVAGI AMGLIKDGDN FVILTDILGD EDHLGDMDFK VAGTRDGVTS
510 520 530 540 550
VQMDIKIKGL SKDIMIKALN QAKEARMFIL DKLYEAIPEP NKEVSKYAPK
560 570 580 590 600
AQVMKIPEDK VGLVIGPAGK NIKYIKEQFG ASVWIDGANA YINAPTIEAV
610 620 630 640 650
NKAADFINSL IQEVEVGGVY EGKVIRVENY GLFVEVLPGK VGLLHASAMT
660 670 680 690 700
EKPTINVGDT IKVKVMAIDE QNRLNLCSPD YQKPENQERP RKEQLNRKPH

HRK
Length:703
Mass (Da):77,809
Last modified:September 23, 2008 - v1
Checksum:i506DDC900A1E0BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG56835.1.
RefSeqiWP_012513192.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG56835; ACG56835; HY04AAS1_0143.
KEGGihya:HY04AAS1_0143.
PATRICi22134910. VBIHydSp64203_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG56835.1.
RefSeqiWP_012513192.1. NC_011126.1.

3D structure databases

ProteinModelPortaliB4U6R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi380749.HY04AAS1_0143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG56835; ACG56835; HY04AAS1_0143.
KEGGihya:HY04AAS1_0143.
PATRICi22134910. VBIHydSp64203_0141.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_HYDS0
AccessioniPrimary (citable) accession number: B4U6R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.