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B4U6R7

- PNP_HYDS0

UniProt

B4U6R7 - PNP_HYDS0

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi482 – 4821MagnesiumUniRule annotation
Metal bindingi488 – 4881MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciHSP380749:GH30-152-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:HY04AAS1_0143
OrganismiHydrogenobaculum sp. (strain Y04AAS1)
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
ProteomesiUP000001872: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703Polyribonucleotide nucleotidyltransferasePRO_1000147923Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380749.HY04AAS1_0143.

Structurei

3D structure databases

ProteinModelPortaliB4U6R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 60759KHUniRule annotationAdd
BLAST
Domaini617 – 67963S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U6R7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVKAEIGNQ DPIYIEANKY AHQADSSILI SQGGTKVLVT VCVSEEPLCG
60 70 80 90 100
IDFAPLSVDY RERSFAWGKI PGGFIKREGK PTDREVLISR VIDRPLRPLM
110 120 130 140 150
PKGFLNEVVV TCLTLSADDK YDPDVLAITG ASAALVSSSV PFEGPIAGMR
160 170 180 190 200
VCRVNGEFII NPTYEQRKNS DMDIVMALSK DAIVMVEGGA KEVEESVLLD
210 220 230 240 250
ALFFGLEKGQ TLIKAQEELV DSLKPEKKPI GHIGLSDDMA NKLKEIASSK
260 270 280 290 300
ILEAFSIEDK KERSKALKDV YAQAMQKLGI SKEQEFDFLV SFKDLESQLM
310 320 330 340 350
REQILKYKKR IDGRKETDIR PITIEMHPLE RPHGSAVFTR GQTQALATVT
360 370 380 390 400
LAPKDEAQLV ETIFEGETFK RFMLHYNFPP FSTGEARPWG PPRRREIGHG
410 420 430 440 450
ALAERALEPL LAKEEDFPYI IRVVSDILES NGSSSMATVC AGSLALFDAG
460 470 480 490 500
VPMKKHVAGI AMGLIKDGDN FVILTDILGD EDHLGDMDFK VAGTRDGVTS
510 520 530 540 550
VQMDIKIKGL SKDIMIKALN QAKEARMFIL DKLYEAIPEP NKEVSKYAPK
560 570 580 590 600
AQVMKIPEDK VGLVIGPAGK NIKYIKEQFG ASVWIDGANA YINAPTIEAV
610 620 630 640 650
NKAADFINSL IQEVEVGGVY EGKVIRVENY GLFVEVLPGK VGLLHASAMT
660 670 680 690 700
EKPTINVGDT IKVKVMAIDE QNRLNLCSPD YQKPENQERP RKEQLNRKPH

HRK
Length:703
Mass (Da):77,809
Last modified:September 23, 2008 - v1
Checksum:i506DDC900A1E0BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG56835.1.
RefSeqiWP_012513192.1. NC_011126.1.
YP_002120813.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG56835; ACG56835; HY04AAS1_0143.
GeneIDi6742930.
KEGGihya:HY04AAS1_0143.
PATRICi22134910. VBIHydSp64203_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG56835.1 .
RefSeqi WP_012513192.1. NC_011126.1.
YP_002120813.1. NC_011126.1.

3D structure databases

ProteinModelPortali B4U6R7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380749.HY04AAS1_0143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG56835 ; ACG56835 ; HY04AAS1_0143 .
GeneIDi 6742930.
KEGGi hya:HY04AAS1_0143.
PATRICi 22134910. VBIHydSp64203_0141.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci HSP380749:GH30-152-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y04AAS1.

Entry informationi

Entry nameiPNP_HYDS0
AccessioniPrimary (citable) accession number: B4U6R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3