B4U6M8 (B4U6M8_HYDS0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL ACG56796.1
EC=2.4.1.182 EMBL ACG56796.1

Gene names

Ordered Locus Names:

HY04AAS1_0104

Organism

Hydrogenobaculum sp. (strain Y04AAS1) [Complete proteome] [HAMAP]

Taxonomic identifier

380749 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Hydrogenobaculum

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ACG56796.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4U6M8 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 720253B503884BEE	FASTA	355	40,941
	10 20 30 40 50 60 MDDLFLSIGD LSAANYVVNI LKHLKDKHLN ISGITDTRME ELGVKPIANI KDLNLVGIIE 70 80 90 100 110 120 VLPKVFKIRK ILNLALEKAN NSRWVILCDA PGFNFRLMKN IKHNHIIYFI SPQVWAWKPQ 130 140 150 160 170 180 RIKEIVKYVR HLIVILPFEL DIYKPYENEH FNVHYFGHPL LDIIKPSSIQ KENIIAMLPG 190 200 210 220 230 240 SRNSEFKRHI GLLEELSYYI YKTFHMKSLI PLASTVDYPI YKKEYIETTK ESSLDVMRRA 250 260 270 280 290 300 KFGIIASGTA SLEASLLGLP HIIFYRLNPI TLQIAKRLVK SKYIGLPNII MDKEIIPELI 310 320 330 340 350 QPSKEDIINV VSSYLENTSK VNAMRENLSF LREKLGPENA TQRIADFIEY ILKSG

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001130 Genomic DNA. Translation: ACG56796.1.
RefSeq	YP_002120774.1. NC_011126.1.
3D structure databases
ProteinModelPortal	B4U6M8.
ModBase	Search...
Protein-protein interaction databases
STRING	B4U6M8.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6742888.
GenomeReviews	Gene locus HY04AAS1_0104 in contig CP001130_GR.
KEGG	hya:HY04AAS1_0104.
PATRIC	22134826. VBIHydSp64203_0102.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B4U6M8_HYDS0

Accession

Primary (citable) accession number: B4U6M8

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)