B4U6B3 (B4U6B3_HYDS0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

HY04AAS1_1567

Organism

Hydrogenobaculum sp. (strain Y04AAS1) [Complete proteome] [HAMAP]

Taxonomic identifier

380749 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Hydrogenobaculum

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862 EMBL ACG58249.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4U6B3 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 9B5FDAE21B196CBE	FASTA	287	32,342
	10 20 30 40 50 60 MKIIELLKNK KGVSFEFFPP KSQKDKEALL ETAKELKVFE PNFVSVTHGA SGNSISQKPP 70 80 90 100 110 120 IEYTKETVLE LKNSLGLNIM AHLTCISHTK DELISILGFY KENSIDNILA LRGDIPKNGE 130 140 150 160 170 180 KRGCSHASEL IDLIKTYFDE SFCIGVAAYP EGHPESPNME WEIKYFKQKV EKGASFAITQ 190 200 210 220 230 240 MFFDNSYYYE FLDLCHKANI NIPIIPGIMP ITNIKQISKF ASMCGATIPS YITDALENLN 250 260 270 280 EEDVVKKGVE IAINQCEDLI KNGIKHIHFY TLNKSKATLQ ILKAIKL

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001130 Genomic DNA. Translation: ACG58249.1.
RefSeq	YP_002122227.1. NC_011126.1.
3D structure databases
ProteinModelPortal	B4U6B3.
ModBase	Search...
Protein-protein interaction databases
STRING	B4U6B3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6744398.
GenomeReviews	Gene locus HY04AAS1_1567 in contig CP001130_GR.
KEGG	hya:HY04AAS1_1567.
PATRIC	22137856. VBIHydSp64203_1572.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK2299700.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B4U6B3_HYDS0

Accession

Primary (citable) accession number: B4U6B3

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)