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B4U5Z5

- B4U5Z5_HYDS0

UniProt

B4U5Z5 - B4U5Z5_HYDS0

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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene
metE, HY04AAS1_1502
Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi641 – 6411Zinc By similarityUniRule annotation
Metal bindingi643 – 6431Zinc By similarityUniRule annotation
Metal bindingi727 – 7271Zinc By similarityUniRule annotation

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHSP380749:GH30-1555-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:HY04AAS1_1502Imported
OrganismiHydrogenobaculum sp. (strain Y04AAS1)Imported
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
ProteomesiUP000001872: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi380749.HY04AAS1_1502.

Structurei

3D structure databases

ProteinModelPortaliB4U5Z5.
SMRiB4U5Z5. Positions 2-754.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000246221.
KOiK00549.
OMAiEYFGELM.
OrthoDBiEOG6FFS3G.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

B4U5Z5-1 [UniParc]FASTAAdd to Basket

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MKALAYGYPK LGEKREFKNA LESFWKKAIT EEQFYEQMRN IEAQRIRAYS    50
ESVDEIPVGE LSFYDFMLDT AVMVGMIPSR FGEYKGLETY FEMARGKSAM 100
EMTKYFNTNY HYIVPELESN NFKLLENKPK RCYLNAKDKV QNPKPYLIAP 150
FTFLKLSKTY KKTTKDGFSV LETSKIENEK TLYYFLEPLL EVYKDILKNL 200
KTEGVNIVSL QDPGLVFDLK DYELNAVKKI YEELSQVSDI ELITYYDSVS 250
AYKDIIDLPV KRIGLDLCSN AENLENLRKY GFPKDKELIA GIINGRQVWR 300
ANLRDKLKLI DELSKIAPNL SISNSSPLFH LPVNVELETK MDKDLKDRLS 350
FAKQKLEELK TLKNAFLGDK ESLKEVEASA KLFEGSFGKN QVVIDRIKAL 400
KDSDFQRELP YKERIKLQQS ILNLPIFPTT TIGSFPQTEE VRKTRSAFRS 450
GKISKQEYEA FIKSQIDNVI AFQEEIGLDV LVHGEFERTD MVEFFAEKLK 500
GVATTEHGWI ISYGSRGYRP PIIYGDVYRD EPMTLNEILY AQSKTQKPVK 550
GMLTGPVTIL NWSFYREDIP KKEVAYQIAL AILDEVKDLE KSGIKIIQID 600
EPAFREGTPI KKKDWEDYFD WAIKSFRLSS KANPKTQIHT HMCYSEFNDI 650
IDKIYDMDFD VISIEASRSK GEILEAFERF GKWDRQIGIG VYDIHSPTIP 700
SVEEMEIVMK RAMKVLDKSL LWVNPDCGLK TRRWEEVKPA LKNMMEMALK 750
LRKEA 755
Length:755
Mass (Da):87,551
Last modified:September 23, 2008 - v1
Checksum:iBA44DC8C4E121C5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG58185.1.
RefSeqiWP_012514541.1. NC_011126.1.
YP_002122163.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG58185; ACG58185; HY04AAS1_1502.
GeneIDi6744333.
KEGGihya:HY04AAS1_1502.
PATRICi22137728. VBIHydSp64203_1508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG58185.1 .
RefSeqi WP_012514541.1. NC_011126.1.
YP_002122163.1. NC_011126.1.

3D structure databases

ProteinModelPortali B4U5Z5.
SMRi B4U5Z5. Positions 2-754.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380749.HY04AAS1_1502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG58185 ; ACG58185 ; HY04AAS1_1502 .
GeneIDi 6744333.
KEGGi hya:HY04AAS1_1502.
PATRICi 22137728. VBIHydSp64203_1508.

Phylogenomic databases

eggNOGi COG0620.
HOGENOMi HOG000246221.
KOi K00549.
OMAi EYFGELM.
OrthoDBi EOG6FFS3G.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci HSP380749:GH30-1555-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y04AAS1.

Entry informationi

Entry nameiB4U5Z5_HYDS0
AccessioniPrimary (citable) accession number: B4U5Z5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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