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B4U5Z5

- B4U5Z5_HYDS0

UniProt

B4U5Z5 - B4U5Z5_HYDS0

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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotationSAAS annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotationSAAS annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi641 – 6411ZincUniRule annotation
Metal bindingi643 – 6431ZincUniRule annotation
Metal bindingi727 – 7271ZincUniRule annotation

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHSP380749:GH30-1555-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:HY04AAS1_1502Imported
OrganismiHydrogenobaculum sp. (strain Y04AAS1)Imported
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
ProteomesiUP000001872: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi380749.HY04AAS1_1502.

Structurei

3D structure databases

ProteinModelPortaliB4U5Z5.
SMRiB4U5Z5. Positions 2-754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000246221.
KOiK00549.
OMAiEYFGELM.
OrthoDBiEOG6FFS3G.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

B4U5Z5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKALAYGYPK LGEKREFKNA LESFWKKAIT EEQFYEQMRN IEAQRIRAYS
60 70 80 90 100
ESVDEIPVGE LSFYDFMLDT AVMVGMIPSR FGEYKGLETY FEMARGKSAM
110 120 130 140 150
EMTKYFNTNY HYIVPELESN NFKLLENKPK RCYLNAKDKV QNPKPYLIAP
160 170 180 190 200
FTFLKLSKTY KKTTKDGFSV LETSKIENEK TLYYFLEPLL EVYKDILKNL
210 220 230 240 250
KTEGVNIVSL QDPGLVFDLK DYELNAVKKI YEELSQVSDI ELITYYDSVS
260 270 280 290 300
AYKDIIDLPV KRIGLDLCSN AENLENLRKY GFPKDKELIA GIINGRQVWR
310 320 330 340 350
ANLRDKLKLI DELSKIAPNL SISNSSPLFH LPVNVELETK MDKDLKDRLS
360 370 380 390 400
FAKQKLEELK TLKNAFLGDK ESLKEVEASA KLFEGSFGKN QVVIDRIKAL
410 420 430 440 450
KDSDFQRELP YKERIKLQQS ILNLPIFPTT TIGSFPQTEE VRKTRSAFRS
460 470 480 490 500
GKISKQEYEA FIKSQIDNVI AFQEEIGLDV LVHGEFERTD MVEFFAEKLK
510 520 530 540 550
GVATTEHGWI ISYGSRGYRP PIIYGDVYRD EPMTLNEILY AQSKTQKPVK
560 570 580 590 600
GMLTGPVTIL NWSFYREDIP KKEVAYQIAL AILDEVKDLE KSGIKIIQID
610 620 630 640 650
EPAFREGTPI KKKDWEDYFD WAIKSFRLSS KANPKTQIHT HMCYSEFNDI
660 670 680 690 700
IDKIYDMDFD VISIEASRSK GEILEAFERF GKWDRQIGIG VYDIHSPTIP
710 720 730 740 750
SVEEMEIVMK RAMKVLDKSL LWVNPDCGLK TRRWEEVKPA LKNMMEMALK

LRKEA
Length:755
Mass (Da):87,551
Last modified:September 23, 2008 - v1
Checksum:iBA44DC8C4E121C5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG58185.1.
RefSeqiWP_012514541.1. NC_011126.1.
YP_002122163.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG58185; ACG58185; HY04AAS1_1502.
GeneIDi6744333.
KEGGihya:HY04AAS1_1502.
PATRICi22137728. VBIHydSp64203_1508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG58185.1 .
RefSeqi WP_012514541.1. NC_011126.1.
YP_002122163.1. NC_011126.1.

3D structure databases

ProteinModelPortali B4U5Z5.
SMRi B4U5Z5. Positions 2-754.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380749.HY04AAS1_1502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG58185 ; ACG58185 ; HY04AAS1_1502 .
GeneIDi 6744333.
KEGGi hya:HY04AAS1_1502.
PATRICi 22137728. VBIHydSp64203_1508.

Phylogenomic databases

eggNOGi COG0620.
HOGENOMi HOG000246221.
KOi K00549.
OMAi EYFGELM.
OrthoDBi EOG6FFS3G.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci HSP380749:GH30-1555-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y04AAS1Imported.

Entry informationi

Entry nameiB4U5Z5_HYDS0
AccessioniPrimary (citable) accession number: B4U5Z5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3