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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotationSAAS annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotationSAAS annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi641ZincUniRule annotation1
Metal bindingi643ZincUniRule annotation1
Metal bindingi727ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHSP380749:G1GCJ-1530-MONOMER
UniPathwayiUPA00051; UER00082

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotationSAAS annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:HY04AAS1_1502Imported
OrganismiHydrogenobaculum sp. (strain Y04AAS1)Imported
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
Proteomesi
  • UP000001872 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi380749.HY04AAS1_1502

Structurei

3D structure databases

ProteinModelPortaliB4U5Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 316Meth_synt_1InterPro annotationAdd BLAST312
Domaini427 – 748Meth_synt_2InterPro annotationAdd BLAST322

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili342 – 362Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatUniRule annotation

Phylogenomic databases

eggNOGiENOG4105DSS Bacteria
COG0620 LUCA
HOGENOMiHOG000246221
KOiK00549
OMAiGRNIWKN
OrthoDBiPOG091H0282

Family and domain databases

Gene3Di3.20.20.2104 hits
HAMAPiMF_00172 Meth_synth, 1 hit
InterProiView protein in InterPro
IPR013215 Cbl-indep_Met_Synth_N
IPR006276 Cobalamin-indep_Met_synthase
IPR002629 Met_Synth_C/arc
IPR038071 UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267 Meth_synt_1, 1 hit
PF01717 Meth_synt_2, 1 hit
PIRSFiPIRSF000382 MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726 SSF51726, 2 hits
TIGRFAMsiTIGR01371 met_syn_B12ind, 1 hit

Sequencei

Sequence statusi: Complete.

B4U5Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALAYGYPK LGEKREFKNA LESFWKKAIT EEQFYEQMRN IEAQRIRAYS
60 70 80 90 100
ESVDEIPVGE LSFYDFMLDT AVMVGMIPSR FGEYKGLETY FEMARGKSAM
110 120 130 140 150
EMTKYFNTNY HYIVPELESN NFKLLENKPK RCYLNAKDKV QNPKPYLIAP
160 170 180 190 200
FTFLKLSKTY KKTTKDGFSV LETSKIENEK TLYYFLEPLL EVYKDILKNL
210 220 230 240 250
KTEGVNIVSL QDPGLVFDLK DYELNAVKKI YEELSQVSDI ELITYYDSVS
260 270 280 290 300
AYKDIIDLPV KRIGLDLCSN AENLENLRKY GFPKDKELIA GIINGRQVWR
310 320 330 340 350
ANLRDKLKLI DELSKIAPNL SISNSSPLFH LPVNVELETK MDKDLKDRLS
360 370 380 390 400
FAKQKLEELK TLKNAFLGDK ESLKEVEASA KLFEGSFGKN QVVIDRIKAL
410 420 430 440 450
KDSDFQRELP YKERIKLQQS ILNLPIFPTT TIGSFPQTEE VRKTRSAFRS
460 470 480 490 500
GKISKQEYEA FIKSQIDNVI AFQEEIGLDV LVHGEFERTD MVEFFAEKLK
510 520 530 540 550
GVATTEHGWI ISYGSRGYRP PIIYGDVYRD EPMTLNEILY AQSKTQKPVK
560 570 580 590 600
GMLTGPVTIL NWSFYREDIP KKEVAYQIAL AILDEVKDLE KSGIKIIQID
610 620 630 640 650
EPAFREGTPI KKKDWEDYFD WAIKSFRLSS KANPKTQIHT HMCYSEFNDI
660 670 680 690 700
IDKIYDMDFD VISIEASRSK GEILEAFERF GKWDRQIGIG VYDIHSPTIP
710 720 730 740 750
SVEEMEIVMK RAMKVLDKSL LWVNPDCGLK TRRWEEVKPA LKNMMEMALK

LRKEA
Length:755
Mass (Da):87,551
Last modified:September 23, 2008 - v1
Checksum:iBA44DC8C4E121C5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA Translation: ACG58185.1
RefSeqiWP_012514541.1, NC_011126.1

Genome annotation databases

EnsemblBacteriaiACG58185; ACG58185; HY04AAS1_1502
KEGGihya:HY04AAS1_1502

Similar proteinsi

Entry informationi

Entry nameiB4U5Z5_HYDS0
AccessioniPrimary (citable) accession number: B4U5Z5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported