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B4U5Z5

- B4U5Z5_HYDS0

UniProt

B4U5Z5 - B4U5Z5_HYDS0

Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotationSAAS annotation

    Catalytic activityi

    5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi641 – 6411ZincUniRule annotation
    Metal bindingi643 – 6431ZincUniRule annotation
    Metal bindingi727 – 7271ZincUniRule annotation

    GO - Molecular functioni

    1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. methionine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHSP380749:GH30-1555-MONOMER.
    UniPathwayiUPA00051; UER00082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
    Alternative name(s):
    Cobalamin-independent methionine synthaseUniRule annotation
    Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
    Gene namesi
    Name:metEUniRule annotation
    Ordered Locus Names:HY04AAS1_1502Imported
    OrganismiHydrogenobaculum sp. (strain Y04AAS1)Imported
    Taxonomic identifieri380749 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
    ProteomesiUP000001872: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi380749.HY04AAS1_1502.

    Structurei

    3D structure databases

    ProteinModelPortaliB4U5Z5.
    SMRiB4U5Z5. Positions 2-754.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

    Keywords - Domaini

    RepeatUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0620.
    HOGENOMiHOG000246221.
    KOiK00549.
    OMAiEYFGELM.
    OrthoDBiEOG6FFS3G.

    Family and domain databases

    HAMAPiMF_00172. Meth_synth.
    InterProiIPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view]
    PfamiPF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4U5Z5-1 [UniParc]FASTAAdd to Basket

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    MKALAYGYPK LGEKREFKNA LESFWKKAIT EEQFYEQMRN IEAQRIRAYS    50
    ESVDEIPVGE LSFYDFMLDT AVMVGMIPSR FGEYKGLETY FEMARGKSAM 100
    EMTKYFNTNY HYIVPELESN NFKLLENKPK RCYLNAKDKV QNPKPYLIAP 150
    FTFLKLSKTY KKTTKDGFSV LETSKIENEK TLYYFLEPLL EVYKDILKNL 200
    KTEGVNIVSL QDPGLVFDLK DYELNAVKKI YEELSQVSDI ELITYYDSVS 250
    AYKDIIDLPV KRIGLDLCSN AENLENLRKY GFPKDKELIA GIINGRQVWR 300
    ANLRDKLKLI DELSKIAPNL SISNSSPLFH LPVNVELETK MDKDLKDRLS 350
    FAKQKLEELK TLKNAFLGDK ESLKEVEASA KLFEGSFGKN QVVIDRIKAL 400
    KDSDFQRELP YKERIKLQQS ILNLPIFPTT TIGSFPQTEE VRKTRSAFRS 450
    GKISKQEYEA FIKSQIDNVI AFQEEIGLDV LVHGEFERTD MVEFFAEKLK 500
    GVATTEHGWI ISYGSRGYRP PIIYGDVYRD EPMTLNEILY AQSKTQKPVK 550
    GMLTGPVTIL NWSFYREDIP KKEVAYQIAL AILDEVKDLE KSGIKIIQID 600
    EPAFREGTPI KKKDWEDYFD WAIKSFRLSS KANPKTQIHT HMCYSEFNDI 650
    IDKIYDMDFD VISIEASRSK GEILEAFERF GKWDRQIGIG VYDIHSPTIP 700
    SVEEMEIVMK RAMKVLDKSL LWVNPDCGLK TRRWEEVKPA LKNMMEMALK 750
    LRKEA 755
    Length:755
    Mass (Da):87,551
    Last modified:September 23, 2008 - v1
    Checksum:iBA44DC8C4E121C5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG58185.1.
    RefSeqiWP_012514541.1. NC_011126.1.
    YP_002122163.1. NC_011126.1.

    Genome annotation databases

    EnsemblBacteriaiACG58185; ACG58185; HY04AAS1_1502.
    GeneIDi6744333.
    KEGGihya:HY04AAS1_1502.
    PATRICi22137728. VBIHydSp64203_1508.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG58185.1 .
    RefSeqi WP_012514541.1. NC_011126.1.
    YP_002122163.1. NC_011126.1.

    3D structure databases

    ProteinModelPortali B4U5Z5.
    SMRi B4U5Z5. Positions 2-754.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380749.HY04AAS1_1502.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG58185 ; ACG58185 ; HY04AAS1_1502 .
    GeneIDi 6744333.
    KEGGi hya:HY04AAS1_1502.
    PATRICi 22137728. VBIHydSp64203_1508.

    Phylogenomic databases

    eggNOGi COG0620.
    HOGENOMi HOG000246221.
    KOi K00549.
    OMAi EYFGELM.
    OrthoDBi EOG6FFS3G.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00082 .
    BioCyci HSP380749:GH30-1555-MONOMER.

    Family and domain databases

    HAMAPi MF_00172. Meth_synth.
    InterProi IPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view ]
    Pfami PF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y04AAS1Imported.

    Entry informationi

    Entry nameiB4U5Z5_HYDS0
    AccessioniPrimary (citable) accession number: B4U5Z5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3