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Protein
Submitted name:

Isocitrate/isopropylmalate dehydrogenase

Gene

HY04AAS1_1432

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. NAD binding Source: InterPro
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciHSP380749:GH30-1480-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate/isopropylmalate dehydrogenaseImported
Gene namesi
Ordered Locus Names:HY04AAS1_1432Imported
OrganismiHydrogenobaculum sp. (strain Y04AAS1)Imported
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
ProteomesiUP000001872: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi380749.HY04AAS1_1432.

Structurei

3D structure databases

ProteinModelPortaliB4U5S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiAMMLEYL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U5S7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MENVCWYDSK ISIPKEGSFI KLKADKTLEV PNNPIIPFIQ GDGIGPEITP
60 70 80 90 100
QMIKVINKAM SKAYNGSKVI YWVEVLAGDM AEQKGLERMP KETLELLKQS
110 120 130 140 150
IVSIKGPLGT PVGKGGKSLN AILRQSMDFY SAIRPVYWMG QPSPIPNPQR
160 170 180 190 200
VNVAVFRENS DDVYMAIEYM PKTDAFKKVR EFFVKEMSVS EDAIPEDAGI
210 220 230 240 250
TVKPMSEFKT KRHVRKAFRY ALQNGKKHIA VAGKGNIMKA TEGMFMNWAF
260 270 280 290 300
EVAKEPEFEG KIITEGEPKE GQAKLYKVIT DQMLMQLVLN PDYYDVIITQ
310 320 330 340 350
NLNGDYISDL ASALVGGPGY VPSGNIGDGY ALFESTHGTA YDIAGKGMAN
360 370 380 390 400
PLSITLSGAM MLEYLGFYEA AGLIYKAIKS VINQRKGTPD IASGFKKMGV
410 420
EAISLTASQF GDAIIDEIDK L
Length:421
Mass (Da):46,392
Last modified:September 23, 2008 - v1
Checksum:i376365BA521FEB6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG58117.1.
RefSeqiWP_012514473.1. NC_011126.1.
YP_002122095.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG58117; ACG58117; HY04AAS1_1432.
GeneIDi6744258.
KEGGihya:HY04AAS1_1432.
PATRICi22137574. VBIHydSp64203_1436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG58117.1.
RefSeqiWP_012514473.1. NC_011126.1.
YP_002122095.1. NC_011126.1.

3D structure databases

ProteinModelPortaliB4U5S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi380749.HY04AAS1_1432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG58117; ACG58117; HY04AAS1_1432.
GeneIDi6744258.
KEGGihya:HY04AAS1_1432.
PATRICi22137574. VBIHydSp64203_1436.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiAMMLEYL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciHSP380749:GH30-1480-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y04AAS1Imported.

Entry informationi

Entry nameiB4U5S7_HYDS0
AccessioniPrimary (citable) accession number: B4U5S7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.