SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4U4X0

- UPPP_STREM

UniProt

B4U4X0 - UPPP_STREM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Undecaprenyl-diphosphatase

Gene
uppP, Sez_1708
Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSEQU552526:GH4P-1742-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Sez_1708
OrganismiStreptococcus equi subsp. zooepidemicus (strain MGCS10565)
Taxonomic identifieri552526 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001873: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed predictionAdd
BLAST
Transmembranei44 – 6421Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei113 – 13321Helical; Reviewed predictionAdd
BLAST
Transmembranei163 – 18321Helical; Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Reviewed predictionAdd
BLAST
Transmembranei225 – 24521Helical; Reviewed predictionAdd
BLAST
Transmembranei255 – 27521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Undecaprenyl-diphosphataseUniRule annotationPRO_1000197409Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi552526.Sez_1708.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U4X0-1 [UniParc]FASTAAdd to Basket

« Hide

MLFIELLKAI FFGVIEGVTE WLPISSTGHL ILVQEFIRLH QDKAFMEMFN    50
IVIQLGAIIA VIVIYFERLN PFQPGKSPQQ IRLTWQLWLK VAIACIPSII 100
IAVPLDDWFD VHFNHMLPIA IALIVYGIAF LWIEKRNQTL EPRVVKLSRM 150
SYKTAFFIGC FQVLSIIPGT SRSGATILGA IILGASRTVA ADFTFFLAIP 200
TMFGYSGLKA LKFFIDGNHL TLSQLLVLLV ASLTAFAVSL YVIKLLTDYV 250
KKHDFTVFGR YRIVLGSLLI VYSVFKSLF 279
Length:279
Mass (Da):31,484
Last modified:September 23, 2008 - v1
Checksum:iBF7BFF4B59FF8607
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001129 Genomic DNA. Translation: ACG63037.1.
RefSeqiYP_002124050.1. NC_011134.1.

Genome annotation databases

EnsemblBacteriaiACG63037; ACG63037; Sez_1708.
GeneIDi6762090.
KEGGisez:Sez_1708.
PATRICi19657408. VBIStrEqu17662_1743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001129 Genomic DNA. Translation: ACG63037.1 .
RefSeqi YP_002124050.1. NC_011134.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 552526.Sez_1708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG63037 ; ACG63037 ; Sez_1708 .
GeneIDi 6762090.
KEGGi sez:Sez_1708.
PATRICi 19657408. VBIStrEqu17662_1743.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SEQU552526:GH4P-1742-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
    Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
    PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGCS10565.

Entry informationi

Entry nameiUPPP_STREM
AccessioniPrimary (citable) accession number: B4U4X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi