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B4U4L7

- B4U4L7_STREM

UniProt

B4U4L7 - B4U4L7_STREM

Protein

Glycerol kinase

Gene

glpK

Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotationSAAS annotation

    Enzyme regulationi

    Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141SubstrateUniRule annotation
    Binding sitei18 – 181ATPUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Binding sitei268 – 2681ATPUniRule annotation
    Binding sitei311 – 3111ATP; via carbonyl oxygenUniRule annotation
    Binding sitei315 – 3151ATP; via amide nitrogenUniRule annotation
    Binding sitei330 – 3301ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 163ATPUniRule annotation
    Nucleotide bindingi412 – 4165ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycerol kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Glycerol metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSEQU552526:GH4P-1632-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
    Alternative name(s):
    ATP:glycerol 3-phosphotransferaseUniRule annotation
    GlycerokinaseUniRule annotation
    Gene namesi
    Name:glpKUniRule annotationImported
    Ordered Locus Names:Sez_1603Imported
    OrganismiStreptococcus equi subsp. zooepidemicus (strain MGCS10565)Imported
    Taxonomic identifieri552526 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001873: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei232 – 2321Phosphohistidine; by HPrUniRule annotation

    Post-translational modificationi

    The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.UniRule annotation

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer and homodimer (in equilibrium).UniRule annotation

    Protein-protein interaction databases

    STRINGi552526.Sez_1603.

    Structurei

    3D structure databases

    ProteinModelPortaliB4U4L7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 852Substrate bindingUniRule annotation
    Regioni246 – 2472Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0554.
    HOGENOMiHOG000222134.
    KOiK00864.
    OMAiHFFGVEV.
    OrthoDBiEOG6RZB46.

    Family and domain databases

    HAMAPiMF_00186. Glycerol_kin.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4U4L7-1 [UniParc]FASTAAdd to Basket

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    MGTETYIMAI DQGTTSSRAI IFNKKGEALV SSQKEFPQLF PQAGWVEHNA    50
    NHIWNSVQSV IADAFIESGI KPEQIEAIGI TNQRETTVVW DKQTGLPIYN 100
    AIVWQSRQTA SIAEQLKRDG YTKMIHEKTG LVIDAYFSAT KLRWLLDHVP 150
    GAQERAERGE LLFGTIDTWL VWKLTDGAVH VTDYSNAART MLYNIKELKW 200
    DDEILTLLNI PRAMLPEVRS NSEIYGKTAP FHFYGGEVVI AGMAGDQQAA 250
    LFGQLAFEPG MVKNTYGTGS FIIMNTGQEA QLSSSNLLTT IGYGINGKVY 300
    YALEGSIFIA GSAVQWLRDG LRMIKTSFES EQLALASTNA DEVYVVPAFT 350
    GLGAPYWDSN ARGSVFGLTR GTTKEDFVKA TLQSIAYQVR DVIDTMQVDS 400
    GITIQQLRVD GGAAMNNMLM QFQADILGID IARAKNLETT ALGAAFLAGL 450
    AVGYWKDMET LKQLNATGQL FKASMSESRR EKLYQGWKRA VKATQFFAEE 500
    L 501
    Length:501
    Mass (Da):55,411
    Last modified:September 23, 2008 - v1
    Checksum:iD17BBAB057591E0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001129 Genomic DNA. Translation: ACG62934.1.
    RefSeqiYP_002123947.1. NC_011134.1.

    Genome annotation databases

    EnsemblBacteriaiACG62934; ACG62934; Sez_1603.
    GeneIDi6761393.
    KEGGisez:Sez_1603.
    PATRICi19657180. VBIStrEqu17662_1635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001129 Genomic DNA. Translation: ACG62934.1 .
    RefSeqi YP_002123947.1. NC_011134.1.

    3D structure databases

    ProteinModelPortali B4U4L7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 552526.Sez_1603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG62934 ; ACG62934 ; Sez_1603 .
    GeneIDi 6761393.
    KEGGi sez:Sez_1603.
    PATRICi 19657180. VBIStrEqu17662_1635.

    Phylogenomic databases

    eggNOGi COG0554.
    HOGENOMi HOG000222134.
    KOi K00864.
    OMAi HFFGVEV.
    OrthoDBi EOG6RZB46.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci SEQU552526:GH4P-1632-MONOMER.

    Family and domain databases

    HAMAPi MF_00186. Glycerol_kin.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
      Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
      PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGCS10565Imported.

    Entry informationi

    Entry nameiB4U4L7_STREM
    AccessioniPrimary (citable) accession number: B4U4L7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3