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B4U4L7

- B4U4L7_STREM

UniProt

B4U4L7 - B4U4L7_STREM

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Protein

Glycerol kinase

Gene

glpK

Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotationSAAS annotation

Enzyme regulationi

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141SubstrateUniRule annotation
Binding sitei18 – 181ATPUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Binding sitei268 – 2681ATPUniRule annotation
Binding sitei311 – 3111ATP; via carbonyl oxygenUniRule annotation
Binding sitei315 – 3151ATP; via amide nitrogenUniRule annotation
Binding sitei330 – 3301ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 163ATPUniRule annotation
Nucleotide bindingi412 – 4165ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

Glycerol metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEQU552526:GH4P-1632-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Gene namesi
Name:glpKUniRule annotationImported
Ordered Locus Names:Sez_1603Imported
OrganismiStreptococcus equi subsp. zooepidemicus (strain MGCS10565)Imported
Taxonomic identifieri552526 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001873: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321Phosphohistidine; by HPrUniRule annotation

Post-translational modificationi

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer and homodimer (in equilibrium).UniRule annotation

Protein-protein interaction databases

STRINGi552526.Sez_1603.

Structurei

3D structure databases

ProteinModelPortaliB4U4L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 852Substrate bindingUniRule annotation
Regioni246 – 2472Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiHFFGVEV.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U4L7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTETYIMAI DQGTTSSRAI IFNKKGEALV SSQKEFPQLF PQAGWVEHNA
60 70 80 90 100
NHIWNSVQSV IADAFIESGI KPEQIEAIGI TNQRETTVVW DKQTGLPIYN
110 120 130 140 150
AIVWQSRQTA SIAEQLKRDG YTKMIHEKTG LVIDAYFSAT KLRWLLDHVP
160 170 180 190 200
GAQERAERGE LLFGTIDTWL VWKLTDGAVH VTDYSNAART MLYNIKELKW
210 220 230 240 250
DDEILTLLNI PRAMLPEVRS NSEIYGKTAP FHFYGGEVVI AGMAGDQQAA
260 270 280 290 300
LFGQLAFEPG MVKNTYGTGS FIIMNTGQEA QLSSSNLLTT IGYGINGKVY
310 320 330 340 350
YALEGSIFIA GSAVQWLRDG LRMIKTSFES EQLALASTNA DEVYVVPAFT
360 370 380 390 400
GLGAPYWDSN ARGSVFGLTR GTTKEDFVKA TLQSIAYQVR DVIDTMQVDS
410 420 430 440 450
GITIQQLRVD GGAAMNNMLM QFQADILGID IARAKNLETT ALGAAFLAGL
460 470 480 490 500
AVGYWKDMET LKQLNATGQL FKASMSESRR EKLYQGWKRA VKATQFFAEE

L
Length:501
Mass (Da):55,411
Last modified:September 23, 2008 - v1
Checksum:iD17BBAB057591E0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001129 Genomic DNA. Translation: ACG62934.1.
RefSeqiYP_002123947.1. NC_011134.1.

Genome annotation databases

EnsemblBacteriaiACG62934; ACG62934; Sez_1603.
GeneIDi6761393.
KEGGisez:Sez_1603.
PATRICi19657180. VBIStrEqu17662_1635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001129 Genomic DNA. Translation: ACG62934.1 .
RefSeqi YP_002123947.1. NC_011134.1.

3D structure databases

ProteinModelPortali B4U4L7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 552526.Sez_1603.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG62934 ; ACG62934 ; Sez_1603 .
GeneIDi 6761393.
KEGGi sez:Sez_1603.
PATRICi 19657180. VBIStrEqu17662_1635.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi HFFGVEV.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci SEQU552526:GH4P-1632-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
    Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
    PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGCS10565Imported.

Entry informationi

Entry nameiB4U4L7_STREM
AccessioniPrimary (citable) accession number: B4U4L7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3