B4U4B1 (AROE_STREM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Sez_1495

Organism

Streptococcus equi subsp. zooepidemicus (strain MGCS10565) [Complete proteome] [HAMAP]

Taxonomic identifier

552526 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000100143
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity
Sites
	Active site	73	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	B4U4B1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 143EC43388AC2202	FASTA	294	31,095
	10 20 30 40 50 60 MLERLSGHTR LTALLAAPAR HSLSPKMHNA AYAKLGLDYA YLAFEVDNSG LAAAVQGMRA 70 80 90 100 110 120 LGICGANVSM PNKQAIVPLL DELSPAAALA GAVNTVVNTD GKGHLVGHIT DGTGAIRSLA 130 140 150 160 170 180 EEGVAIKDQI ITIAGAGGAG TAIAVQLGLD GAKEIRLFNR KTATFKQAKQ VLKGINAKTS 190 200 210 220 230 240 ALASLQDLAD DRAFRRSIAE SSIYIDATGV GMKPLEEHSL ITDPALIRPD LVVFDLVYHP 250 260 270 280 290 AETKLLAFAR EHGAKKVMNG LGMLLYQGAE AFKLMTGEDM PVAYIRELLC RNKE

References

[1]

"Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease." Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M. PLoS ONE 3:E3026-E3026(2008) [PubMed: 18716664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGCS10565.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001129 Genomic DNA. Translation: ACG62828.1.
RefSeq	YP_002123841.1. NC_011134.1.
3D structure databases
ProteinModelPortal	B4U4B1.
ModBase	Search...
Protein-protein interaction databases
STRING	B4U4B1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000009514; EBSTRP00000009075; EBSTRG00000009514.
GeneID	6761924.
GenomeReviews	Gene locus Sez_1495 in contig CP001129_GR.
KEGG	sez:Sez_1495.
PATRIC	19656941. VBIStrEqu17662_1527.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027337.
HOGENOM	HBG553408.
OMA	SIYIDAT.
ProtClustDB	CLSK698780.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROE_STREM

Accession

Primary (citable) accession number: B4U4B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program