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B4U3E1

- PYRF_STREM

UniProt

B4U3E1 - PYRF_STREM

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, Sez_1159
Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei34 – 341Substrate By similarity
Active sitei63 – 631Proton donor By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei188 – 1881Substrate By similarity
Binding sitei208 – 2081Substrate; via amide nitrogen By similarity
Binding sitei209 – 2091Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSEQU552526:GH4P-1184-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Sez_1159
OrganismiStreptococcus equi subsp. zooepidemicus (strain MGCS10565)
Taxonomic identifieri552526 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001873: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000138559Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi552526.Sez_1159.

Structurei

3D structure databases

ProteinModelPortaliB4U3E1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 7010Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U3E1-1 [UniParc]FASTAAdd to Basket

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MREERPIIAL DFPSFEEVKS FLSLFPADER LYVKIGMELY YAEGPDIVRY    50
VKSLGHSVFL DLKLHDIPNT VKSTMAVLSR LGIDMTTVQA AGGVEMLRAA 100
REGLGQGPIL IAVTQLTSTS EEQMREDQNI QSTLLASVLH YAKRTAQAKL 150
DGVVCSAHEV KAIKSEVPAG FVCLTPGIRP TGADIGDQKR VMTPHQARAI 200
GSDYIVLGRP ITQATDPVKA YHQIKAEWNR 230
Length:230
Mass (Da):25,318
Last modified:September 23, 2008 - v1
Checksum:i103BF7BA64203C78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001129 Genomic DNA. Translation: ACG62508.1.
RefSeqiYP_002123521.1. NC_011134.1.

Genome annotation databases

EnsemblBacteriaiACG62508; ACG62508; Sez_1159.
GeneIDi6762001.
KEGGisez:Sez_1159.
PATRICi19656252. VBIStrEqu17662_1185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001129 Genomic DNA. Translation: ACG62508.1 .
RefSeqi YP_002123521.1. NC_011134.1.

3D structure databases

ProteinModelPortali B4U3E1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 552526.Sez_1159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG62508 ; ACG62508 ; Sez_1159 .
GeneIDi 6762001.
KEGGi sez:Sez_1159.
PATRICi 19656252. VBIStrEqu17662_1185.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SEQU552526:GH4P-1184-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
    Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
    PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGCS10565.

Entry informationi

Entry nameiPYRF_STREM
AccessioniPrimary (citable) accession number: B4U3E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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