B4U2T6 (FTHS_STREM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	Sez_0945

Organism

Streptococcus equi subsp. zooepidemicus (strain MGCS10565) [Complete proteome] [HAMAP]

Taxonomic identifier

552526 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus dysgalactiae group › Streptococcus equi › Streptococcus equi subsp. zooepidemicus

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543		PRO_1000196825
Regions
	Nucleotide binding	65 – 72	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4U2T6 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 6EEE31A9E5D71EB5	FASTA	556	59,434
	10 20 30 40 50 60 MKSDIEIAQS VPLKPITEIV KKVGIDGDDL ELYGNYKAKL SFEKIKSVKG NKPGKLILVT 70 80 90 100 110 120 AINPTPAGEG KSTMSIGLAD ALTKIGKKTM LALREPSLGP VMGIKGGAAG GGYAQVLPME 130 140 150 160 170 180 DINLHFTGDM HAITTAHNAL SALIDNHLQQ GNELGIDPRR IIWKRVLDLN DRSLRQVIVG 190 200 210 220 230 240 LGSPVNGVPR EDGFDITVAS EVMAILCLAT DLKDLKARLA NIVIAYRYDK SPVYVRDLKV 250 260 270 280 290 300 EGALALILKD AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 310 320 330 340 350 360 FGADLGAEKF LNIKTPNLPK APDAVVIVAT LRALKMHGGV AKADLTFENT AAVRSGFANL 370 380 390 400 410 420 KRHVENIRKF NIPVVVAINE FVTDTKAEIQ VLKELCAEIA VPVELASVWA KGADGGIALA 430 440 450 460 470 480 NAVVSAIAEE SAAYKRLYAD KDSLEEKLRA IVTEIYGGRT VQFGPKAKNQ LKQFAQYGWD 490 500 510 520 530 540 QLPVCMAKTQ YSFSDDPSLL GAPDQFDITI RELVPKTGAG FIVALTGDVM TMPGLPKIPA 550 AMKMDVTEDG TAVGLF

References

[1]

"Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease." Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M. PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGCS10565.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001129 Genomic DNA. Translation: ACG62303.1.
RefSeq	YP_002123316.1. NC_011134.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	552526.Sez_0945.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACG62303; ACG62303; Sez_0945.
GeneID	6760791.
KEGG	sez:Sez_0945.
PATRIC	19655815. VBIStrEqu17662_0970.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
OMA	EEPAHYT.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	SEQU552526:GH4P-972-MONOMER.
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_STREM

Accession

Primary (citable) accession number: B4U2T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	May 29, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program