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B4U246 (AROA_STREM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:Sez_0700
OrganismStreptococcus equi subsp. zooepidemicus (strain MGCS10565) [Complete proteome] [HAMAP]
Taxonomic identifier552526 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4274273-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000099755

Sequences

Sequence LengthMass (Da)Tools
B4U246 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 645F0A2069473BB4

FASTA42746,023
        10         20         30         40         50         60 
MKLRTKAKAL RGRLRVPGDK SISHRAVIFG AIAEGQTVIH GLLRGQDVLA TIQAFRDLGV 

        70         80         90        100        110        120 
TIYESADSLI IEGRGFKGLK PAQKPLDMGN SGTSMRLLAG LLAAQDFSVQ LFGDDSLSRR 

       130        140        150        160        170        180 
PMDRITIPLS LMGAELSGQG EKELPPLIVK GCQGLRPIHY QLPVASAQVK SAILLAALQT 

       190        200        210        220        230        240 
QGETVILEKE LTRNHTEEMI EQFGGKLSVA GKQISIKGPQ RLQGQTLQIP GDLSSAAFWL 

       250        260        270        280        290        300 
AAGLIVPGSD LVLENVGINP TRTGLLEVIE KMGGQLSYQA VDKDIQTATL KVSYSTLKGI 

       310        320        330        340        350        360 
EISGDLIPRL IDELPVIALL ATQAQGTTYI RDAQELRVKE TDRIQAVTDV LGQMGADIQA 

       370        380        390        400        410        420 
TEDGMVIRGK TPLHGAAVST CGDHRIGMMT AIAALLVEEG QVTLERAEAI LTSYPDFFKD 


LERLWHD

« Hide

References

[1]"Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
PLoS ONE 3:E3026-E3026(2008) [PubMed: 18716664] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGCS10565.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001129 Genomic DNA. Translation: ACG62063.1.
RefSeqYP_002123076.1. NC_011134.1.

3D structure databases

ProteinModelPortalB4U246.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4U246.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000009645; EBSTRP00000009206; EBSTRG00000009645.
GeneID6761672.
GenomeReviewsGene locus Sez_0700 in contig CP001129_GR.
KEGGsez:Sez_0700.
PATRIC19655320. VBIStrEqu17662_0724.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000028044.
HOGENOMHBG646626.
OMAFANVSES.
ProtClustDBPRK02427.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_STREM
AccessionPrimary (citable) accession number: B4U246
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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