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B4U1Z2 (DDL_STREM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Sez_0642
OrganismStreptococcus equi subsp. zooepidemicus (strain MGCS10565) [Complete proteome] [HAMAP]
Taxonomic identifier552526 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000116639

Regions

Domain132 – 334203ATP-grasp
Nucleotide binding162 – 21756ATP By similarity

Sites

Metal binding2881Magnesium or manganese 1 By similarity
Metal binding3011Magnesium or manganese 1 By similarity
Metal binding3011Magnesium or manganese 2 By similarity
Metal binding3031Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B4U1Z2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 5A1E266C7C157740

FASTA34838,789
        10         20         30         40         50         60 
MSKQTLILLY GGRSAEREVS VLSAESVMRA IDYTKFFVKT YFISQTGQFI KTQEFSSQPA 

        70         80         90        100        110        120 
ATERLMTNAT IRLEQQIRPS DIYEEGAVVF PVLHGPMGED GSIQGFLEVL KMPYVGTNIL 

       130        140        150        160        170        180 
SSSVAMDKIT TKRVLESADI PQVAYTVYIE GQDLDRCLAE TEAVLSYPVF VKPANMGSSV 

       190        200        210        220        230        240 
GISKAESEEE LRAAILLALT YDSRILIEQG VLAREIEVGL LGNTDVKSTL PGEVVKNVDF 

       250        260        270        280        290        300 
YDYQAKYIDN EITMAIPAAI DESAMTSMRT YAETAFKAIG ACGLSRCDFF LGQDGQIYLN 

       310        320        330        340 
ELNTMPGFTQ WSMYPLLWEH MGLSYAELIE ELVRLAQEMF EKREGHLI 

« Hide

References

[1]"Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGCS10565.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001129 Genomic DNA. Translation: ACG62009.1.
RefSeqYP_002123022.1. NC_011134.1.

3D structure databases

ProteinModelPortalB4U1Z2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING552526.Sez_0642.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACG62009; ACG62009; Sez_0642.
GeneID6761808.
KEGGsez:Sez_0642.
PATRIC19655199. VBIStrEqu17662_0664.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycSEQU552526:GH4P-671-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_STREM
AccessionPrimary (citable) accession number: B4U1Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways