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B4U1G6

- LACG_STREM

UniProt

B4U1G6 - LACG_STREM

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Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donorUniRule annotation
Active sitei375 – 3751NucleophileUniRule annotation

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSEQU552526:GH4P-493-MONOMER.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
Short name:
PGALaseUniRule annotation
P-beta-GalUniRule annotation
Short name:
PBGUniRule annotation
Gene namesi
Name:lacGUniRule annotation
Ordered Locus Names:Sez_0461
OrganismiStreptococcus equi subsp. zooepidemicus (strain MGCS10565)
Taxonomic identifieri552526 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001873: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4694696-phospho-beta-galactosidasePRO_1000147419Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi552526.Sez_0461.

Structurei

3D structure databases

ProteinModelPortaliB4U1G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088632.
KOiK01220.
OMAiNRWYLDP.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U1G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKRLPDDFI FGGATAAYQA EGATTIDGKG AVAWDRYLKD NYWYTAEPAS
60 70 80 90 100
DFYHQYPIDL ALAEQFGING IRISIAWSRI FPEGFGEVNA KGVAFYHSLF
110 120 130 140 150
AECHKHHVEP FVTLHHFDTP EALHSRGDFL NRENIDHFVA YAAYCFKEFP
160 170 180 190 200
EVSYWTTFNE IGPIGDGQYL VGKFPPGISY DLAKVFQSHH NMMLAHARAL
210 220 230 240 250
VHYKEQAYPG EIGIVHALPT KYPLDPTNPA DVLAAELDDI IHNKFILDAT
260 270 280 290 300
YLGQYSEKTM AGVKHILAEN GGSLDLRPED FELLQAAKDL NDFLGINYYM
310 320 330 340 350
SDWLRAFDGE TEIIHNGKGE KGGSKYQIKG VGQRIFDVDV PRTDWDWMIY
360 370 380 390 400
PQGLYDQIMR IKADYPGYKK IYITENGLGY KDTCIDGRID DDARIDYIKQ
410 420 430 440 450
HLAVIADVIS AGANVKGYFI WSLMDVFSWS NGYDKRYGLF YVDFETQKRY
460
PKKSAYWYQQ LAATKTISV
Length:469
Mass (Da):53,462
Last modified:September 23, 2008 - v1
Checksum:i26FA2980DE9B644E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001129 Genomic DNA. Translation: ACG61833.1.
RefSeqiWP_012515109.1. NC_011134.1.
YP_002122846.1. NC_011134.1.

Genome annotation databases

EnsemblBacteriaiACG61833; ACG61833; Sez_0461.
GeneIDi6761327.
KEGGisez:Sez_0461.
PATRICi19654824. VBIStrEqu17662_0477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001129 Genomic DNA. Translation: ACG61833.1 .
RefSeqi WP_012515109.1. NC_011134.1.
YP_002122846.1. NC_011134.1.

3D structure databases

ProteinModelPortali B4U1G6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 552526.Sez_0461.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG61833 ; ACG61833 ; Sez_0461 .
GeneIDi 6761327.
KEGGi sez:Sez_0461.
PATRICi 19654824. VBIStrEqu17662_0477.

Phylogenomic databases

eggNOGi COG2723.
HOGENOMi HOG000088632.
KOi K01220.
OMAi NRWYLDP.
OrthoDBi EOG60658J.

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
BioCyci SEQU552526:GH4P-493-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
    Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
    PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGCS10565.

Entry informationi

Entry nameiLACG_STREM
AccessioniPrimary (citable) accession number: B4U1G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3