Reviewed, UniProtKB/Swiss-Prot B4U1G6 (LACG_STREM)

Names and origin

Protein names

Recommended name:
    6-phospho-beta-galactosidase
    EC=3.2.1.85
Alternative name(s):
    Beta-D-phosphogalactoside galactohydrolase
      Short name=PGALase
    P-beta-Gal
      Short name=PBG

Gene names

Name:	lacG
Ordered Locus Names:	Sez_0461

Organism

Streptococcus equi subsp. zooepidemicus (strain MGCS10565) [Complete proteome] [HAMAP]

Taxonomic identifier

552526 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP MF_01574
Pathway	Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP MF_01574
Sequence similarities	Belongs to the glycosyl hydrolase 1 family.

Ontologies

Keywords
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: InterPro
Molecular function	6-phospho-beta-galactosidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro galactosidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	6-phospho-beta-galactosidase HAMAP MF_01574		PRO_1000147419
Sites
	Active site	160	1	Proton donor By similarity
	Active site	375	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4U1G6-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 26FA2980DE9B644E	FASTA	469	53,462
	10 20 30 40 50 60 MIKRLPDDFI FGGATAAYQA EGATTIDGKG AVAWDRYLKD NYWYTAEPAS DFYHQYPIDL 70 80 90 100 110 120 ALAEQFGING IRISIAWSRI FPEGFGEVNA KGVAFYHSLF AECHKHHVEP FVTLHHFDTP 130 140 150 160 170 180 EALHSRGDFL NRENIDHFVA YAAYCFKEFP EVSYWTTFNE IGPIGDGQYL VGKFPPGISY 190 200 210 220 230 240 DLAKVFQSHH NMMLAHARAL VHYKEQAYPG EIGIVHALPT KYPLDPTNPA DVLAAELDDI 250 260 270 280 290 300 IHNKFILDAT YLGQYSEKTM AGVKHILAEN GGSLDLRPED FELLQAAKDL NDFLGINYYM 310 320 330 340 350 360 SDWLRAFDGE TEIIHNGKGE KGGSKYQIKG VGQRIFDVDV PRTDWDWMIY PQGLYDQIMR 370 380 390 400 410 420 IKADYPGYKK IYITENGLGY KDTCIDGRID DDARIDYIKQ HLAVIADVIS AGANVKGYFI 430 440 450 460 WSLMDVFSWS NGYDKRYGLF YVDFETQKRY PKKSAYWYQQ LAATKTISV

References

[1]

"Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease." Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M. PLoS ONE 3:E3026-E3026(2008) [PubMed: 18716664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001129 Genomic DNA. Translation: ACG61833.1.
RefSeq	YP_002122846.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6761327.
GenomeReviews	Gene locus Sez_0461 in contig CP001129_GR.
KEGG	sez:Sez_0461.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TKYPLDP.
Family and domain databases
HAMAP	MF_01574. [Tree]
InterPro	IPR001360. Glyco_hydro_1. IPR018120. Glyco_hydro_1_AS. IPR013781. Glyco_hydro_sg_catalytic. IPR005928. LacG. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PANTHER	PTHR10353. Glyco_hydro_1. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 1 hit. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
TIGRFAMs	TIGR01233. lacG. 1 hit.
PROSITE	PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit. PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LACG_STREM

Accession

Primary (citable) accession number: B4U1G6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)