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B4U1B3 (FABH_STREM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3

EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:Sez_0406
OrganismStreptococcus equi subsp. zooepidemicus (strain MGCS10565) [Complete proteome] [HAMAP]
Taxonomic identifier552526 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP-Rule MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP-Rule MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP-Rule MF_01815

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01815

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP-Rule MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3243243-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP-Rule MF_01815
PRO_1000187897

Regions

Region250 – 2545ACP-binding By similarity

Sites

Active site1121 By similarity
Active site2491 By similarity
Active site2791 By similarity

Sequences

Sequence LengthMass (Da)Tools
B4U1B3 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 05A13E419E3DDD91

FASTA32434,833
        10         20         30         40         50         60 
MVFSKISQVA HYTPKQVISN DDLSQIMDTS HEWISSRTGI EKRHISTVEM TSDLAIRVAE 

        70         80         90        100        110        120 
QLLAGSGYDA TALDFIIVAT ISPDASMPST AAKVQAAIGA TNAFAFDMTA ACSGFVFALA 

       130        140        150        160        170        180 
MADKLIASGA YQRGLVIGAE TLSKIIDWQD RSTAVLFGDG AGGVLLEASE QQHFLAEALH 

       190        200        210        220        230        240 
TDGARSQSLT SGQSSLRSPF SQGQEVNSFL QMDGRAIFDF AIRDVSRSIA AIIEQSGLAK 

       250        260        270        280        290        300 
EELDYLLLHQ ANRRILDKMA KKIGMPREKF LENMMHYGNT SAASIPILLS ESVQNGQLKL 

       310        320 
DGSQHILLSG FGGGLTWGSL IVKI 

« Hide

References

[1]"Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease."
Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M.
PLoS ONE 3:E3026-E3026(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGCS10565.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001129 Genomic DNA. Translation: ACG61780.1.
RefSeqYP_002122793.1. NC_011134.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING552526.Sez_0406.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACG61780; ACG61780; Sez_0406.
GeneID6760685.
KEGGsez:Sez_0406.
PATRIC19654703. VBIStrEqu17662_0418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHOG000246674.
KOK00648.
OMAIRIMEAA.
OrthoDBEOG6J74XN.

Enzyme and pathway databases

BioCycSEQU552526:GH4P-438-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
HAMAPMF_01815. FabH.
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 1 hit.
TIGRFAMsTIGR00747. fabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_STREM
AccessionPrimary (citable) accession number: B4U1B3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways