B4U178 (ALR_STREM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	Sez_0369

Organism

Streptococcus equi subsp. zooepidemicus (strain MGCS10565) [Complete proteome] [HAMAP]

Taxonomic identifier

552526 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: InterPro cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Alanine racemase HAMAP MF_01201		PRO_1000138625
Sites
	Active site	40	1	Proton acceptor; specific for D-alanine By similarity
	Active site	263	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	40	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4U178 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 35614E47486130AD	FASTA	366	40,143
	10 20 30 40 50 60 MISSLHRPTV ARVDLEAIQA NIDKIQRHIP KKVKTYAVVK ANAYGHGAVA VSKAVEDQVD 70 80 90 100 110 120 GYCVSNLDEA LELRQAGIDK EILILGVILA SELQLAIKHQ LTITVASLEW LELAKKESVD 130 140 150 160 170 180 FSQLHVHVKV DSGMGRIGVR SLAEANQLIS ILSDMGVQLD GIFTHFATAD ESDHAMFDKQ 190 200 210 220 230 240 LTFFKQLVEQ LDKRPALVHA SNSATSLWHS ETIFNAIRLG IVIYGLNPSG NSLSLPCPLK 250 260 270 280 290 300 EALSLESRLV HVKQIQAGDS VGYGASYVAA ESEYVGTLPI GYADGWTRNM QGFKVLVEGE 310 320 330 340 350 360 FCDIIGRVSM DQLTIRLLQA YPIGTKVTLI GQQGKQVITA TDVADYRGTI NYEVLCLLSD RIPREY

References

[1]

"Genome sequence of a lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease." Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R., Musser J.M. PLoS ONE 3:E3026-E3026(2008) [PubMed: 18716664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGCS10565.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001129 Genomic DNA. Translation: ACG61745.1.
RefSeq	YP_002122758.1. NC_011134.1.
3D structure databases
ProteinModelPortal	B4U178.
ModBase	Search...
Protein-protein interaction databases
STRING	B4U178.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000009842; EBSTRP00000009403; EBSTRG00000009842.
GeneID	6760729.
GenomeReviews	Gene locus Sez_0369 in contig CP001129_GR.
KEGG	sez:Sez_0369.
PATRIC	19654627. VBIStrEqu17662_0380.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000028408.
HOGENOM	HBG712172.
OMA	TRKEDAN.
ProtClustDB	PRK00053.
Family and domain databases
HAMAP	MF_01201. Ala_racemase. [Tree]
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01775.
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. Alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_STREM

Accession

Primary (citable) accession number: B4U178

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program