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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEQU552526:G1GCI-261-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Sez_0227
OrganismiStreptococcus equi subsp. zooepidemicus (strain MGCS10565)
Taxonomic identifieri552526 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001873 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000901091 – 481Glutamate--tRNA ligaseAdd BLAST481

Proteomic databases

PRIDEiB4U0R8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4U0R8
SMRiB4U0R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi255 – 259"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252720
KOiK09698
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B4U0R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPIRVRYA PSPTGLLHIG NARTALFNYL YARHHGGDFV IRIEDTDRKR
60 70 80 90 100
HVEDGERSQL ENLRWLGIDW DESPETHERY RQSERLALYQ QYIDQLLAEG
110 120 130 140 150
KAYKSYVTEE ELAAERERQE AAGETPRYVN EYLGMSADEK AAYIAEREAA
160 170 180 190 200
GIVPTVRLAV NEAGIYKWTD MVKGDIVFEG GNVGGDWVIQ KKDGYPTYNF
210 220 230 240 250
AVVIDDHDMQ ISHVIRGDDH IANTPKQLMV YEALGWEAPV FGHMTLIINS
260 270 280 290 300
ETGKKLSKRD TNTLQFIEDY RKKGYMPEAV FNFIALLGWN PGGEAEIFSR
310 320 330 340 350
EQLIALFDES RLSKSPAAFD QKKMDWMSNE YFKHADLGAV YALCKPFLEA
360 370 380 390 400
AGRLTEKAEK LVELYQPQLS SADEIVPLTD LFFSDFPELT AKEKEVMAAE
410 420 430 440 450
TVPTVLKAFK EKLEAMSDED FKPENIFPQI KAVQKETGIK GKNLFMPIRI
460 470 480
AVSGEMHGPE LPNTIYLLGR EQSIEHIANM L
Length:481
Mass (Da):54,733
Last modified:September 23, 2008 - v1
Checksum:i1E9DFB5EAACE0F97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001129 Genomic DNA Translation: ACG61605.1
RefSeqiWP_012514887.1, NC_011134.1

Genome annotation databases

EnsemblBacteriaiACG61605; ACG61605; Sez_0227
KEGGisez:Sez_0227

Similar proteinsi

Entry informationi

Entry nameiSYE_STREM
AccessioniPrimary (citable) accession number: B4U0R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health