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Protein

2,3-diketo-L-gulonate reductase

Gene

dlgD

Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 174NADUniRule annotation7
Nucleotide bindingi224 – 225NADUniRule annotation2
Nucleotide bindingi304 – 306NADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate reductaseUniRule annotation (EC:1.1.1.130UniRule annotation)
Short name:
2,3-DKG reductaseUniRule annotation
Alternative name(s):
3-dehydro-L-gulonate 2-dehydrogenaseUniRule annotation
Gene namesi
Name:dlgDUniRule annotation
Ordered Locus Names:SeSA_A3866
OrganismiSalmonella schwarzengrund (strain CVM19633)
Taxonomic identifieri439843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001865 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001343521 – 3322,3-diketo-L-gulonate reductaseAdd BLAST332

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4TZ64
SMRiB4TZ64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249660
KOiK08092
OMAiDILCGVM

Family and domain databases

HAMAPiMF_00820 Diketo_gul_reduc, 1 hit
InterProiView protein in InterPro
IPR023689 Diketo_gul_Rdtase
IPR036111 Mal/L-sulfo/L-lacto_DH-like_sf
IPR003767 Malate/L-lactate_DH-like
PANTHERiPTHR11091 PTHR11091, 1 hit
PfamiView protein in Pfam
PF02615 Ldh_2, 1 hit
SUPFAMiSSF89733 SSF89733, 1 hit

Sequencei

Sequence statusi: Complete.

B4TZ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTFEELKG AFYRVLRSRN IAEDTADACA EMFARTTESG VYSHGVNRFP
60 70 80 90 100
RFIQQLDNGD IIPDAKPQRV TSLGAIEQWD AQRAIGNLTA KKMMDRAIEL
110 120 130 140 150
ASDHGIGLVA LRNANHWMRG GSYGWQAAEK GYIGICWTNS IAVMPPWGAK
160 170 180 190 200
ECRIGTNPLI VAIPSTPITM VDMSMSMFSY GMLEVNRLAG RELPVDGGFD
210 220 230 240 250
DNGQLTKEPG VIEKNRRILP MGYWKGSGLS IVLDMIATLL SNGSSVAEVT
260 270 280 290 300
QENSDEYGVS QIFIAIEVDK LIDGATRDAK LQRIMDFITT AERADDNVAI
310 320 330
RLPGHEFTKL LDDNRRHGIT IDDSVWAKIQ AL
Length:332
Mass (Da):36,713
Last modified:September 23, 2008 - v1
Checksum:iF78537CB83CC8A48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001127 Genomic DNA Translation: ACF92796.1
RefSeqiWP_000869008.1, NC_011094.1

Genome annotation databases

EnsemblBacteriaiACF92796; ACF92796; SeSA_A3866
KEGGisew:SeSA_A3866

Similar proteinsi

Entry informationi

Entry nameiDLGD_SALSV
AccessioniPrimary (citable) accession number: B4TZ64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health