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B4TWN7

- LSPA_SALSV

UniProt

B4TWN7 - LSPA_SALSV

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Protein

Lipoprotein signal peptidase

Gene
lspA, SeSA_A0051
Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141 By similarity
Active sitei141 – 1411 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciSENT439843:GHHR-1857-MONOMER.
UniPathwayiUPA00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidase (EC:3.4.23.36)
Alternative name(s):
Prolipoprotein signal peptidase
Signal peptidase II
Short name:
SPase II
Gene namesi
Name:lspA
Ordered Locus Names:SeSA_A0051
OrganismiSalmonella schwarzengrund (strain CVM19633)
Taxonomic identifieri439843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001865: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Reviewed predictionAdd
BLAST
Transmembranei70 – 9021Helical; Reviewed predictionAdd
BLAST
Transmembranei102 – 12221Helical; Reviewed predictionAdd
BLAST
Transmembranei137 – 15721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Lipoprotein signal peptidaseUniRule annotationPRO_1000097280Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439843.SeSA_A0051.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0597.
HOGENOMiHOG000096993.
OMAiDFASKQW.
OrthoDBiEOG6PGKBM.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4TWN7-1 [UniParc]FASTAAdd to Basket

« Hide

MSKPLCSTGL RWLWLVVVVL IIDLGSKYLI LQNFALGDTV GLFPSLNLHY    50
ARNYGAAFSF LADSGGWQRW FFAGIAIGIC VILLVMMYRS KATQKLNNIA 100
YALIIGGALG NLFDRLWHGF VVDMIDFYVG DWHFATFNLA DSAICIGAAL 150
IVLEGFLPKP TAKEQA 166
Length:166
Mass (Da):18,340
Last modified:September 23, 2008 - v1
Checksum:iCEDFB731F759C4A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001127 Genomic DNA. Translation: ACF90428.1.
RefSeqiYP_002113058.1. NC_011094.1.

Genome annotation databases

EnsemblBacteriaiACF90428; ACF90428; SeSA_A0051.
PATRICi32368793. VBISalEnt87589_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001127 Genomic DNA. Translation: ACF90428.1 .
RefSeqi YP_002113058.1. NC_011094.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439843.SeSA_A0051.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF90428 ; ACF90428 ; SeSA_A0051 .
PATRICi 32368793. VBISalEnt87589_0174.

Phylogenomic databases

eggNOGi COG0597.
HOGENOMi HOG000096993.
OMAi DFASKQW.
OrthoDBi EOG6PGKBM.

Enzyme and pathway databases

UniPathwayi UPA00665 .
BioCyci SENT439843:GHHR-1857-MONOMER.

Family and domain databases

HAMAPi MF_00161. LspA.
InterProi IPR001872. Peptidase_A8.
[Graphical view ]
Pfami PF01252. Peptidase_A8. 1 hit.
[Graphical view ]
PRINTSi PR00781. LIPOSIGPTASE.
TIGRFAMsi TIGR00077. lspA. 1 hit.
PROSITEi PS00855. SPASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CVM19633.

Entry informationi

Entry nameiLSPA_SALSV
AccessioniPrimary (citable) accession number: B4TWN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi