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B4TT49

- MSRA_SALSV

UniProt

B4TT49 - MSRA_SALSV

Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

    Catalytic activityi

    Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
    L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521UniRule annotation

    GO - Molecular functioni

    1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular protein modification process Source: UniProtKB-HAMAP
    2. protein repair Source: InterPro
    3. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciSENT439843:GHHR-2999-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
    Short name:
    Protein-methionine-S-oxide reductaseUniRule annotation
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductaseUniRule annotation
    Short name:
    Peptide Met(O) reductaseUniRule annotation
    Gene namesi
    Name:msrAUniRule annotation
    Ordered Locus Names:SeSA_A4676
    OrganismiSalmonella schwarzengrund (strain CVM19633)
    Taxonomic identifieri439843 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001865: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Peptide methionine sulfoxide reductase MsrAPRO_1000145436Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439843.SeSA_A4676.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0225.
    HOGENOMiHOG000263862.
    OMAiYAGGQTP.
    OrthoDBiEOG6091JX.

    Family and domain databases

    Gene3Di3.30.1060.10. 1 hit.
    HAMAPiMF_01401. MsrA.
    InterProiIPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view]
    PANTHERiPTHR10173. PTHR10173. 1 hit.
    PfamiPF01625. PMSR. 1 hit.
    [Graphical view]
    SUPFAMiSSF55068. SSF55068. 1 hit.
    TIGRFAMsiTIGR00401. msrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4TT49-1 [UniParc]FASTAAdd to Basket

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    MSLFDKKHLV TQADALPGRN TPMPIATLHA VNEHSMTNVP AGMEIAYFAM    50
    GCFWGVERLF WQLPGVYSTA AGYAGGYTPN PTYREVCSGQ TGHAEAVRIV 100
    YDPAVIRYEQ LLQIFWENHD PTQGMQQGND HGTQYRSAIY PLTPEQSAAA 150
    HASRERFQSA MAAAGNHRPI TTEITHATPF YYAEDEHQQY LHKNPYGYCG 200
    IGGIGVCLPP DA 212
    Length:212
    Mass (Da):23,450
    Last modified:September 23, 2008 - v1
    Checksum:i4AFBF6FA2A3FBA02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001127 Genomic DNA. Translation: ACF91525.1.
    RefSeqiYP_002117347.1. NC_011094.1.

    Genome annotation databases

    EnsemblBacteriaiACF91525; ACF91525; SeSA_A4676.
    PATRICi32377910. VBISalEnt87589_4631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001127 Genomic DNA. Translation: ACF91525.1 .
    RefSeqi YP_002117347.1. NC_011094.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439843.SeSA_A4676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF91525 ; ACF91525 ; SeSA_A4676 .
    PATRICi 32377910. VBISalEnt87589_4631.

    Phylogenomic databases

    eggNOGi COG0225.
    HOGENOMi HOG000263862.
    OMAi YAGGQTP.
    OrthoDBi EOG6091JX.

    Enzyme and pathway databases

    BioCyci SENT439843:GHHR-2999-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1060.10. 1 hit.
    HAMAPi MF_01401. MsrA.
    InterProi IPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view ]
    PANTHERi PTHR10173. PTHR10173. 1 hit.
    Pfami PF01625. PMSR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55068. SSF55068. 1 hit.
    TIGRFAMsi TIGR00401. msrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CVM19633.

    Entry informationi

    Entry nameiMSRA_SALSV
    AccessioniPrimary (citable) accession number: B4TT49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3