Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B4TT49 (MSRA_SALSV) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA

Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase
Gene names
Name:msrA
Ordered Locus Names:SeSA_A4676
OrganismSalmonella schwarzengrund (strain CVM19633) [Complete proteome] [HAMAP]
Taxonomic identifier439843 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401
PRO_1000145436

Sites

Active site521 By similarity

Sequences

Sequence LengthMass (Da)Tools
B4TT49 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 4AFBF6FA2A3FBA02

FASTA21223,450
        10         20         30         40         50         60 
MSLFDKKHLV TQADALPGRN TPMPIATLHA VNEHSMTNVP AGMEIAYFAM GCFWGVERLF 

        70         80         90        100        110        120 
WQLPGVYSTA AGYAGGYTPN PTYREVCSGQ TGHAEAVRIV YDPAVIRYEQ LLQIFWENHD 

       130        140        150        160        170        180 
PTQGMQQGND HGTQYRSAIY PLTPEQSAAA HASRERFQSA MAAAGNHRPI TTEITHATPF 

       190        200        210 
YYAEDEHQQY LHKNPYGYCG IGGIGVCLPP DA 

« Hide

References

[1]"Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CVM19633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001127 Genomic DNA. Translation: ACF91525.1.
RefSeqYP_002117347.1. NC_011094.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439843.SeSA_A4676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF91525; ACF91525; SeSA_A4676.
PATRIC32377910. VBISalEnt87589_4631.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0225.
HOGENOMHOG000263862.
OMAYAGGQTP.
OrthoDBEOG6091JX.

Enzyme and pathway databases

BioCycSENT439843:GHHR-2999-MONOMER.

Family and domain databases

Gene3D3.30.1060.10. 1 hit.
HAMAPMF_01401. MsrA.
InterProIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERPTHR10173. PTHR10173. 1 hit.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. SSF55068. 1 hit.
TIGRFAMsTIGR00401. msrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA_SALSV
AccessionPrimary (citable) accession number: B4TT49
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families