B4TT49 (MSRA_SALSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	SeSA_A4676

Organism

Salmonella schwarzengrund (strain CVM19633) [Complete proteome] [HAMAP]

Taxonomic identifier

439843 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella enterica subsp. enterica serovar Schwarzengrund

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular_function	peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401		PRO_1000145436
Sites
	Active site	52	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4TT49 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 4AFBF6FA2A3FBA02	FASTA	212	23,450
	10 20 30 40 50 60 MSLFDKKHLV TQADALPGRN TPMPIATLHA VNEHSMTNVP AGMEIAYFAM GCFWGVERLF 70 80 90 100 110 120 WQLPGVYSTA AGYAGGYTPN PTYREVCSGQ TGHAEAVRIV YDPAVIRYEQ LLQIFWENHD 130 140 150 160 170 180 PTQGMQQGND HGTQYRSAIY PLTPEQSAAA HASRERFQSA MAAAGNHRPI TTEITHATPF 190 200 210 YYAEDEHQQY LHKNPYGYCG IGGIGVCLPP DA

References

[1]

"Complete genome of Salmonella schwarzengrund strain CVM19633." Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., Leclerc J., Cebula T., Sebastian Y. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CVM19633.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001127 Genomic DNA. Translation: ACF91525.1.
RefSeq	YP_002117347.1. NC_011094.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	439843.SeSA_A4676.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACF91525; ACF91525; SeSA_A4676.
GeneID	6517612.
KEGG	sew:SeSA_A4676.
PATRIC	32377910. VBISalEnt87589_4631.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HOG000263862.
KO	K07304.
OMA	SAIYCTT.
ProtClustDB	PRK00058.
Enzyme and pathway databases
BioCyc	SENT439843:GHHR-2999-MONOMER.
Family and domain databases
Gene3D	3.30.1060.10. 1 hit.
HAMAP	MF_01401. MsrA.
InterPro	IPR002569. Met_Sox_Rdtase_MsrA. [Graphical view]
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_SALSV

Accession

Primary (citable) accession number: B4TT49

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program