Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glyoxylate/hydroxypyruvate reductase A

Gene

ghrA

Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.UniRule annotation

Catalytic activityi

Glycolate + NADP+ = glyoxylate + NADPH.UniRule annotation
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227UniRule annotation1
Active sitei275Proton donorUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate/hydroxypyruvate reductase AUniRule annotation (EC:1.1.1.79UniRule annotation, EC:1.1.1.81UniRule annotation)
Alternative name(s):
2-ketoacid reductaseUniRule annotation
Gene namesi
Name:ghrAUniRule annotation
Ordered Locus Names:SeSA_A1200
OrganismiSalmonella schwarzengrund (strain CVM19633)
Taxonomic identifieri439843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001865 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001872811 – 312Glyoxylate/hydroxypyruvate reductase AAdd BLAST312

Structurei

3D structure databases

ProteinModelPortaliB4TSP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000136694.
KOiK12972.
OMAiHKAIPQA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01666. 2_Hacid_dh_C_GhrA. 1 hit.
InterProiIPR006140. D-isomer_DH_NAD-bd.
IPR023514. GhrA.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

B4TSP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIFYHPTF NAAWWVNALE KALPHARVRE WKVGDNNPAD YALVWQPPVE
60 70 80 90 100
MLAGRRLKAV FALGAGVDAI LSKLNAHPEM LDASIPLFRL EDTGMGLQMQ
110 120 130 140 150
EYAVSQVLHW FRRFDDYQAL KNQALWKPLP EYTREEFSVG IMGAGVLGAK
160 170 180 190 200
VAESLQAWGF PLRCWSRSRK SWPGVESYVG REELRAFLNQ TRVLINLLPN
210 220 230 240 250
TAQTVGIINS ELLDQLPDGA YVLNLARGVH VQEADLLAAL DSGKLKGAML
260 270 280 290 300
DVFSQEPLPQ ESPLWRHPRV AMTPHIAAVT RPAEAIDYIS RTITQLEKGE
310
PVTGQVDRAR GY
Length:312
Mass (Da):35,006
Last modified:September 23, 2008 - v1
Checksum:iA46D750625A7A501
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001127 Genomic DNA. Translation: ACF89061.1.
RefSeqiWP_000402552.1. NC_011094.1.

Genome annotation databases

EnsemblBacteriaiACF89061; ACF89061; SeSA_A1200.
KEGGisew:SeSA_A1200.
PATRICi32371059. VBISalEnt87589_1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001127 Genomic DNA. Translation: ACF89061.1.
RefSeqiWP_000402552.1. NC_011094.1.

3D structure databases

ProteinModelPortaliB4TSP5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF89061; ACF89061; SeSA_A1200.
KEGGisew:SeSA_A1200.
PATRICi32371059. VBISalEnt87589_1282.

Phylogenomic databases

HOGENOMiHOG000136694.
KOiK12972.
OMAiHKAIPQA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01666. 2_Hacid_dh_C_GhrA. 1 hit.
InterProiIPR006140. D-isomer_DH_NAD-bd.
IPR023514. GhrA.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGHRA_SALSV
AccessioniPrimary (citable) accession number: B4TSP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.