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B4TRH4

- B4TRH4_SALSV

UniProt

B4TRH4 - B4TRH4_SALSV

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Protein
Alanine racemase
Gene
alr, SeSA_A4495
Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei129 – 1291Substrate By similarityUniRule annotation
Active sitei255 – 2551Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSENT439843:GHHR-2052-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SeSA_A4495Imported
OrganismiSalmonella schwarzengrund (strain CVM19633)Imported
Taxonomic identifieri439843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001865: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Proteomic databases

PRIDEiB4TRH4.

Interactioni

Protein-protein interaction databases

STRINGi439843.SeSA_A4495.

Structurei

3D structure databases

ProteinModelPortaliB4TRH4.
SMRiB4TRH4. Positions 1-359.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
OMAiLWQLEAI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4TRH4-1 [UniParc]FASTAAdd to Basket

« Hide

MQAATVVINR RALRHNLQRL RELAPASKLV AVVKANAYGH GLLETARTLP    50
DADAFGVARL EEALRLRAGG ITQPILLLEG FFDAADLPTI SAQCLHTAVH 100
NQEQLAALEA VELAEPVTVW MKLDTGMHRL GVRPEEAEAF YQRLTHCKNV 150
RQPVNIVSHF ARADEPECGA TEHQLDIFNA FCQGKPGQRS IAASGGILLW 200
PQSHFDWARP GIILYGVSPL EHKPWGPDFG FQPVMSLTSS LIAVRDHKAG 250
EPVGYGGTWV SERDTRLGVV AMGYGDGYPR AAPSGTPVLV NGREVPIVGR 300
VAMDMICVDL GPNAQDNAGD PVVLWGEGLP VERIAEMTKV SAYELITRLT 350
SRVAMKYID 359
Length:359
Mass (Da):39,076
Last modified:September 23, 2008 - v1
Checksum:iB6527AED8263D65B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001127 Genomic DNA. Translation: ACF90614.1.
RefSeqiYP_002117180.1. NC_011094.1.

Genome annotation databases

EnsemblBacteriaiACF90614; ACF90614; SeSA_A4495.
PATRICi32377549. VBISalEnt87589_4454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001127 Genomic DNA. Translation: ACF90614.1 .
RefSeqi YP_002117180.1. NC_011094.1.

3D structure databases

ProteinModelPortali B4TRH4.
SMRi B4TRH4. Positions 1-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439843.SeSA_A4495.

Proteomic databases

PRIDEi B4TRH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF90614 ; ACF90614 ; SeSA_A4495 .
PATRICi 32377549. VBISalEnt87589_4454.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031446.
OMAi LWQLEAI.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SENT439843:GHHR-2052-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CVM19633Imported.

Entry informationi

Entry nameiB4TRH4_SALSV
AccessioniPrimary (citable) accession number: B4TRH4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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