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B4TR76

- PUR5_SALSV

UniProt

B4TR76 - PUR5_SALSV

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT439843:GHHR-4364-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:SeSA_A2737
    OrganismiSalmonella schwarzengrund (strain CVM19633)
    Taxonomic identifieri439843 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001865: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000193042Add
    BLAST

    Proteomic databases

    PRIDEiB4TR76.

    Interactioni

    Protein-protein interaction databases

    STRINGi439843.SeSA_A2737.

    Structurei

    3D structure databases

    ProteinModelPortaliB4TR76.
    SMRiB4TR76. Positions 5-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4TR76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDKTSLSYK DAGVDIDAGN ALVDRIKGVV KKTRRPEVMG GLGGFGALCA    50
    LPQKYREPVL VSGTDGVGTK LRLAMDLKRH DAIGIDLVAM CVNDLVVQGA 100
    EPLFFLDYYA TGKLDVDTAA SVINGIAEGC LQSGCALVGG ETAEMPGMYH 150
    GEDYDVAGFC VGVVEKSEII DGSRVAEGDV LIALGSSGPH SNGYSLVRKI 200
    IDVSGCDPQT TLLEGKPLAD HLLEPTRIYV KSVLELIENV DVHAIAHLTG 250
    GGFWENIPRV LPENTQAVIN ESSWQWPAIF TWLQTAGNVS RHEMYRTFNC 300
    GVGMVIALSA PEADKALALL NEKGENAWKI GIIKASDSEQ RVVIE 345
    Length:345
    Mass (Da):36,900
    Last modified:September 23, 2008 - v1
    Checksum:iDF7141C812A9D908
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001127 Genomic DNA. Translation: ACF92847.1.
    RefSeqiYP_002115566.1. NC_011094.1.

    Genome annotation databases

    EnsemblBacteriaiACF92847; ACF92847; SeSA_A2737.
    PATRICi32374111. VBISalEnt87589_2786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001127 Genomic DNA. Translation: ACF92847.1 .
    RefSeqi YP_002115566.1. NC_011094.1.

    3D structure databases

    ProteinModelPortali B4TR76.
    SMRi B4TR76. Positions 5-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439843.SeSA_A2737.

    Proteomic databases

    PRIDEi B4TR76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF92847 ; ACF92847 ; SeSA_A2737 .
    PATRICi 32374111. VBISalEnt87589_2786.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci SENT439843:GHHR-4364-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CVM19633.

    Entry informationi

    Entry nameiPUR5_SALSV
    AccessioniPrimary (citable) accession number: B4TR76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3