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B4TPU7

- GLPK_SALSV

UniProt

B4TPU7 - GLPK_SALSV

Protein

Glycerol kinase

Gene

glpK

Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

    Enzyme regulationi

    Activity of this regulatory enzyme is affected by several metabolites. Allosterically and non-competitively inhibited by fructose 1,6-bisphosphate (FBP) and unphosphorylated phosphocarrier protein EIIA-Glc (III-Glc), an integral component of the bacterial phosphotransferase (PTS) system.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141SubstrateUniRule annotation
    Binding sitei18 – 181ATPUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Binding sitei268 – 2681ATPUniRule annotation
    Binding sitei311 – 3111ATP; via carbonyl oxygenUniRule annotation
    Binding sitei315 – 3151ATP; via amide nitrogenUniRule annotation
    Binding sitei330 – 3301ATPUniRule annotation
    Metal bindingi479 – 4791Zinc; shared with EIIA-GlcUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 163ATPUniRule annotation
    Nucleotide bindingi412 – 4165ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
    2. glycerol catabolic process Source: UniProtKB-UniPathway
    3. glycerol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSENT439843:GHHR-1874-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
    Alternative name(s):
    ATP:glycerol 3-phosphotransferaseUniRule annotation
    GlycerokinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:glpKUniRule annotation
    Ordered Locus Names:SeSA_A4302
    OrganismiSalmonella schwarzengrund (strain CVM19633)
    Taxonomic identifieri439843 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001865: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Glycerol kinasePRO_1000098761Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer and homodimer (in equilibrium). Heterodimer with EIIA-Glc. Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.UniRule annotation

    Protein-protein interaction databases

    STRINGi439843.SeSA_A4302.

    Structurei

    3D structure databases

    ProteinModelPortaliB4TPU7.
    SMRiB4TPU7. Positions 3-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 852Substrate bindingUniRule annotation
    Regioni234 – 2363Allosteric FBP inhibitor binding
    Regioni246 – 2472Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0554.
    HOGENOMiHOG000222134.
    OMAiHFFGVEV.
    OrthoDBiEOG6RZB46.

    Family and domain databases

    HAMAPiMF_00186. Glycerol_kin.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4TPU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEKKYIVAL DQGTTSSRAV VMDHDANIVS VSQREFEQIY PKPGWVEHDP    50
    MEIWASQSST LVEVLAKADI SSDQIAAIGI TNQRETAIVW ERETGKPIYN 100
    AIVWQCRRTA DICEQLKRDG LEDYIRDNTG LVVDPYFSGT KVKWILDHVE 150
    GSRERAKRGE LLFGTVDTWL IWKMTQGRVH VTDYTNASRT MLFNIHDLDW 200
    DDKMLDVLDI PRAMLPQVRK SSEVYGQTNI GGKGGTRIPI AGIAGDQQAA 250
    LFGQLCVKEG MAKNTYGTGC FMLMNTGEKA VKSENGLLTT IACGPSGEVN 300
    YALEGAVFMA GASIQWLRDE MKLISDAFDS EYFATKVKDT NGVYVVPAFT 350
    GLGAPYWDPY ARGAIFGLTR GVNSNHIIRA TLESIAYQTR DVLEAMQADS 400
    GIRLHALRVD GGAVANNFLM QFQSDILGTR VERPEVREVT ALGAAYLAGL 450
    AVGYWQNLDE LQEKAVIERE FRPGIETTER NYRYSGWKKA VKRAMAWEEH 500
    DK 502
    Length:502
    Mass (Da):56,052
    Last modified:September 23, 2008 - v1
    Checksum:iA780A522CA16C1B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001127 Genomic DNA. Translation: ACF90443.1.
    RefSeqiYP_002117007.1. NC_011094.1.

    Genome annotation databases

    EnsemblBacteriaiACF90443; ACF90443; SeSA_A4302.
    PATRICi32377167. VBISalEnt87589_4275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001127 Genomic DNA. Translation: ACF90443.1 .
    RefSeqi YP_002117007.1. NC_011094.1.

    3D structure databases

    ProteinModelPortali B4TPU7.
    SMRi B4TPU7. Positions 3-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439843.SeSA_A4302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF90443 ; ACF90443 ; SeSA_A4302 .
    PATRICi 32377167. VBISalEnt87589_4275.

    Phylogenomic databases

    eggNOGi COG0554.
    HOGENOMi HOG000222134.
    OMAi HFFGVEV.
    OrthoDBi EOG6RZB46.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci SENT439843:GHHR-1874-MONOMER.

    Family and domain databases

    HAMAPi MF_00186. Glycerol_kin.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CVM19633.

    Entry informationi

    Entry nameiGLPK_SALSV
    AccessioniPrimary (citable) accession number: B4TPU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3