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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

Gene

arnT

Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis

This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciSENT439843:GHHR-315-MONOMER.
UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseUniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferaseUniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferaseUniRule annotation
Gene namesi
Name:arnTUniRule annotation
Ordered Locus Names:SeSA_A2529
OrganismiSalmonella schwarzengrund (strain CVM19633)
Taxonomic identifieri439843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001865 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalUniRule annotationAdd
BLAST
Transmembranei82 – 10221HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei137 – 15721HelicalUniRule annotationAdd
BLAST
Transmembranei163 – 18523HelicalUniRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalUniRule annotationAdd
BLAST
Transmembranei256 – 27621HelicalUniRule annotationAdd
BLAST
Transmembranei289 – 30921HelicalUniRule annotationAdd
BLAST
Transmembranei311 – 33121HelicalUniRule annotationAdd
BLAST
Transmembranei345 – 36521HelicalUniRule annotationAdd
BLAST
Transmembranei381 – 40121HelicalUniRule annotationAdd
BLAST
Transmembranei405 – 42521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferasePRO_0000380034Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000273002.
KOiK07264.
OMAiAWRIFRD.
OrthoDBiEOG6NKQWN.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4TPI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSIRYYLA FAAFIALYYV IPVNSRLLWQ PDETRYAEIS REMLASGDWI
60 70 80 90 100
VPHFLGLRYF EKPIAGYWIN SLGQWLFGAT NFGVRAGAIL TTLLAAALVA
110 120 130 140 150
WLTFRLWRDK RTALLASVIF LSLFAVYSIG TYAVLDPMIA LWLTAGMCCF
160 170 180 190 200
WQGMQATTRT GKIGMFLLLG ATCGLGVLTK GFLALAVPVV SVLPWVIVQK
210 220 230 240 250
RWKDFLLYGW LAVLSCFVVV LPWAIAIARR EADFWHYFFW VEHIQRFAMS
260 270 280 290 300
DAQHKAPFWY YLPVLLAGSL PWLGLLPGAL KLGWRERNGA FYLLGWTIMP
310 320 330 340 350
LLFFSIAKGK LPTYVLSCFA PIAILMARFV LHNVKEGVAA LRVNGGINLV
360 370 380 390 400
FGLVGIVAAF VVSSWGPLKS PVWTHIETYK VFCVWGVFTV WAFVGWYSLC
410 420 430 440 450
HSQKYLLPAF CPLGLALLFG FSVPDRVMES KQPQFFVEMT QAPLASSRYI
460 470 480 490 500
LVDNVGVAAG LAWSLKRDDI MLYGHAGELR YGLSYPDVQD KFVKADDFNA
510 520 530 540
WLNQHRQEGI ITLVLSIAKD EDISALSLPP ADNIDYQGRL VLIQYRPK
Length:548
Mass (Da):61,805
Last modified:September 23, 2008 - v1
Checksum:i8FEA3F83ADFD8397
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001127 Genomic DNA. Translation: ACF88928.1.
RefSeqiWP_000978056.1. NC_011094.1.

Genome annotation databases

EnsemblBacteriaiACF88928; ACF88928; SeSA_A2529.
KEGGisew:SeSA_A2529.
PATRICi32373699. VBISalEnt87589_2587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001127 Genomic DNA. Translation: ACF88928.1.
RefSeqiWP_000978056.1. NC_011094.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF88928; ACF88928; SeSA_A2529.
KEGGisew:SeSA_A2529.
PATRICi32373699. VBISalEnt87589_2587.

Phylogenomic databases

HOGENOMiHOG000273002.
KOiK07264.
OMAiAWRIFRD.
OrthoDBiEOG6NKQWN.

Enzyme and pathway databases

UniPathwayiUPA00037.
BioCyciSENT439843:GHHR-315-MONOMER.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CVM19633.

Entry informationi

Entry nameiARNT_SALSV
AccessioniPrimary (citable) accession number: B4TPI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: December 9, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.