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B4TNT2

- GPPA_SALSV

UniProt

B4TNT2 - GPPA_SALSV

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, SeSA_A4125
Organism
Salmonella schwarzengrund (strain CVM19633)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSENT439843:GHHR-4111-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:SeSA_A4125
OrganismiSalmonella schwarzengrund (strain CVM19633)
Taxonomic identifieri439843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001865: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_1000192539Add
BLAST

Proteomic databases

PRIDEiB4TNT2.

Interactioni

Protein-protein interaction databases

STRINGi439843.SeSA_A4125.

Structurei

3D structure databases

ProteinModelPortaliB4TNT2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4TNT2-1 [UniParc]FASTAAdd to Basket

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MNSTSLYAAI DLGSNSFHML VVREAAGSIQ TLTRIKRKVR LAAGLNNDNH    50
LSAEAMERGW QCLRLFAERL QDIPQPQIRV VATATLRLAV NAGEFIAKAQ 100
TILGCPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG 150
AQTTSLFSLS MGCVTWLERY FSDRNLAQEN FDDAEKAARD VLRPVADELR 200
FHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE 250
LEIEGLTLER ALVFPSGLAI LIAIFTELNI QSMTLAGGAL REGLVYGMLH 300
LAVDQDIRSR TLRNIQRRFI VDTDQANRVA KLADNFLKQV ENAWHIEPIS 350
RELLLSACQL HEIGLSVDFK QAPYHAAYLV RHLDLPGYTP AQKKLLATLL 400
LNQTNPVDLS SLHQQNAVPP RVAEQLCRLL RLAILFAGRR RDDLVPEITL 450
QALNENLTLT LPGDWLAHHP LGKELIDQES QWQSYVHWPL DVR 493
Length:493
Mass (Da):54,816
Last modified:September 23, 2008 - v1
Checksum:i992697E61F583EF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001127 Genomic DNA. Translation: ACF92605.1.
RefSeqiYP_002116849.1. NC_011094.1.

Genome annotation databases

EnsemblBacteriaiACF92605; ACF92605; SeSA_A4125.
PATRICi32376823. VBISalEnt87589_4111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001127 Genomic DNA. Translation: ACF92605.1 .
RefSeqi YP_002116849.1. NC_011094.1.

3D structure databases

ProteinModelPortali B4TNT2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 439843.SeSA_A4125.

Proteomic databases

PRIDEi B4TNT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF92605 ; ACF92605 ; SeSA_A4125 .
PATRICi 32376823. VBISalEnt87589_4111.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci SENT439843:GHHR-4111-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CVM19633.

Entry informationi

Entry nameiGPPA_SALSV
AccessioniPrimary (citable) accession number: B4TNT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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