true2009-07-282024-03-2783CYSG_SALHSComparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution.Fricke W.F.Mammel M.K.McDermott P.F.Tartera C.White D.G.Leclerc J.E.Ravel J.Cebula T.A.doi:10.1128/jb.00297-112011J. Bacteriol.1933556-3568NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]SL476SUMTNAD(P)-binding Rossmann-like DomainSirohaem synthase, dimerisation domainSiroheme_synth4pyrrol_Mease4pyrrol_Methylase_sf4pyrrole_Mease_sub14pyrrole_Mease_sub2CobA/CysG_CNAD(P)-bd_dom_sfSirohaem_synt_dimer_dom_sfSirohaem_synthSirohaem_synthase_centralSirohaem_synthase_dimer_domSirohaem_synthase_NUropor_MeTrfase_CScobA_cysG_CtermcysG_NtermSIROHEME SYNTHASESIROHEME SYNTHASE-RELATEDCysG_dimeriserNAD_binding_7Sirohm_synth_MTP_methylaseSirohaem_synthNAD(P)-binding Rossmann-fold domainsSiroheme synthase middle domains-likeTetrapyrrole methylaseSUMT_1SUMT_2Siroheme synthaseUroporphyrinogen-III C-methyltransferaseUrogen III methylase2.1.1.107SUMTUroporphyrinogen III methylaseUROMPrecorrin-2 dehydrogenase1.3.1.76Sirohydrochlorin ferrochelatase4.99.1.4cysGSeHA_C3784Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.In the C-terminal section; belongs to the precorrin methyltransferase family.Siroheme synthase501731457Precorrin-2 dehydrogenase /sirohydrochlorin ferrochelatase204Uroporphyrinogen-III C-methyltransferase216Proton acceptor248Proton donor27022234344225301303306331332382411Phosphoserine1282008-09-23150173fedeb9310d281f61bb2de0ffc0cb4ec5MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTINALTFIPQFTVWANEGMLTLVEGPFDETLLDSCWLAIAATDDDTVNQRVSDAAESRRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPQHLGQVARYAGQLRARVKKQFATMGERRRFWEKFFVNDRLAQSLANADEKAVNATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVHGVLTQLGELAQQVESPALIIVGRVVGLRDKLNWFSNYtrue