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Protein

Glutathione-regulated potassium-efflux system ancillary protein KefG

Gene

kefG

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.UniRule annotation

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT454169:GHYG-3737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione-regulated potassium-efflux system ancillary protein KefGUniRule annotation
Alternative name(s):
Putative quinone oxidoreductase KefGUniRule annotation (EC:1.6.5.2UniRule annotation)
Gene namesi
Name:kefGUniRule annotation
Ordered Locus Names:SeHA_C3763
OrganismiSalmonella heidelberg (strain SL476)
Taxonomic identifieri454169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Glutathione-regulated potassium-efflux system ancillary protein KefGPRO_1000145585Add
BLAST

Proteomic databases

PRIDEiB4TKN3.

Interactioni

Subunit structurei

Interacts with KefB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4TKN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000149972.
KOiK11748.
OMAiALAGKYW.
OrthoDBiEOG628F94.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

B4TKN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPAKVLLL YAHPESQDSV ANRVLLKPAI QHNNVTVHDL YARYPDFFID
60 70 80 90 100
TPYEQALLRE HDVIVFQHPL YTYSCPALLK EWLDRVLSRG FASGPGGNQL
110 120 130 140 150
VGKYWRSVIT TGEPESAYRY DALNRYPMSD VLRPFELTAA MCRMHWMPPI
160 170 180
IVYWARRQSP QTLASHAKAY GEWLANPVSA GGY
Length:183
Mass (Da):20,927
Last modified:September 23, 2008 - v1
Checksum:i165E328B928BD9EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF68050.1.
RefSeqiWP_000081820.1. NC_011083.1.

Genome annotation databases

EnsemblBacteriaiACF68050; ACF68050; SeHA_C3763.
KEGGiseh:SeHA_C3763.
PATRICi18515002. VBISalEnt43179_3570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF68050.1.
RefSeqiWP_000081820.1. NC_011083.1.

3D structure databases

ProteinModelPortaliB4TKN3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4TKN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF68050; ACF68050; SeHA_C3763.
KEGGiseh:SeHA_C3763.
PATRICi18515002. VBISalEnt43179_3570.

Phylogenomic databases

HOGENOMiHOG000149972.
KOiK11748.
OMAiALAGKYW.
OrthoDBiEOG628F94.

Enzyme and pathway databases

BioCyciSENT454169:GHYG-3737-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL476.

Entry informationi

Entry nameiKEFG_SALHS
AccessioniPrimary (citable) accession number: B4TKN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: January 20, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.