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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:SeHA_C1930
OrganismiSalmonella heidelberg (strain SL476)
Taxonomic identifieri454169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000989151 – 486Cardiolipin synthase AAdd BLAST486

Structurei

3D structure databases

ProteinModelPortaliB4TJM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077403.
KOiK06131.
OMAiFFKQDSG.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4TJM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFYTVVSW LVILGYWVLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV
60 70 80 90 100
GIIAYLSVGE LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAQENSSVA
110 120 130 140 150
SSLFKLCERR QGIAGVKGNQ LQLLTDSDDV MQALIRDIQL ARHNIEMVFY
160 170 180 190 200
IWQPGGMADQ VAESLMAAAR RGIHCRLMLD SAGSVAFFRS PWAAMMRNAG
210 220 230 240 250
IEVVEALKVN LMRVFLRRMD LRQHRKMVMI DNYIAYTGSM NMVDPRFFKQ
260 270 280 290 300
DAGVGQWVDL MARMEGPVAT AMGIVYSCDW EIETGKRILP PPPDVNIMPF
310 320 330 340 350
EQASGHTIHT IASGPGFPED LIHQALLTAT YAAREYLIMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIILPR KNDSLLVGWA SRAFFSELLA AGVKIYQFEG
410 420 430 440 450
GLLHTKSVLV DGELSLVGTV NLDMRSLWLN FEITLVIDDT GFGADLAAVQ
460 470 480
DDYISRSRLL DARLWVKRPL WQRITERLFY FFSPLL
Length:486
Mass (Da):54,734
Last modified:September 23, 2008 - v1
Checksum:i08A6E76F45541FD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF66484.1.
RefSeqiWP_000206886.1. NC_011083.1.

Genome annotation databases

EnsemblBacteriaiACF66484; ACF66484; SeHA_C1930.
KEGGiseh:SeHA_C1930.
PATRICi18511528. VBISalEnt43179_1873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF66484.1.
RefSeqiWP_000206886.1. NC_011083.1.

3D structure databases

ProteinModelPortaliB4TJM2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF66484; ACF66484; SeHA_C1930.
KEGGiseh:SeHA_C1930.
PATRICi18511528. VBISalEnt43179_1873.

Phylogenomic databases

HOGENOMiHOG000077403.
KOiK06131.
OMAiFFKQDSG.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLSA_SALHS
AccessioniPrimary (citable) accession number: B4TJM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.