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Protein

Ribosomal RNA large subunit methyltransferase G

Gene

rlmG

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1835) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSENT454169:GHYG-3492-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase GUniRule annotation (EC:2.1.1.174UniRule annotation)
Alternative name(s):
23S rRNA m2G1835 methyltransferaseUniRule annotation
rRNA (guanine-N(2)-)-methyltransferase RlmGUniRule annotation
Gene namesi
Name:rlmGUniRule annotation
Ordered Locus Names:SeHA_C3515
OrganismiSalmonella heidelberg (strain SL476)
Taxonomic identifieri454169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Ribosomal RNA large subunit methyltransferase GPRO_0000366495Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB4TIU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmG family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246323.
KOiK11391.
OMAiFHQQQVV.
OrthoDBiEOG67X1ZC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01859. 23SrRNA_methyltr_G.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
PIRSFiPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

B4TIU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHVDDGFRS LTLKRFPQTD DVNPLLAWEA ADEYLLQQLD ETEIRGPVLI
60 70 80 90 100
LNDTFGALSC ALAEHSPYSI GDSYLSELGT RENLRHNGIA ESSVTFLDST
110 120 130 140 150
ADYPQAPGVV LIKVPKTLAL LEQQLRALRK VVTAQTRIIA GAKARDIHTS
160 170 180 190 200
TLELFEKVLG PTTTTLAWKK ARLINCTFSH PQLADAPQTL NWKLEDTGWT
210 220 230 240 250
IHNHANVFSR TGLDIGARFF MQHLPENLDG EIVDLGCGNG VIGLSLLAKN
260 270 280 290 300
PQANVVFVDE SPMAVDSSRL NVETNLPEAF ERCEFMINNA LSGVEPFRFN
310 320 330 340 350
AVFCNPPFHQ KHALTDNIAW EMFHHARRCL KINGELYIVA NRHLDYFHKL
360 370
KKIFGNCATI ATNNKFVILK AVKQGRRR
Length:378
Mass (Da):42,299
Last modified:September 23, 2008 - v1
Checksum:iE657135A458CDB21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF68755.1.
RefSeqiWP_000019983.1. NC_011083.1.

Genome annotation databases

EnsemblBacteriaiACF68755; ACF68755; SeHA_C3515.
KEGGiseh:SeHA_C3515.
PATRICi18514536. VBISalEnt43179_3345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF68755.1.
RefSeqiWP_000019983.1. NC_011083.1.

3D structure databases

ProteinModelPortaliB4TIU8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF68755; ACF68755; SeHA_C3515.
KEGGiseh:SeHA_C3515.
PATRICi18514536. VBISalEnt43179_3345.

Phylogenomic databases

HOGENOMiHOG000246323.
KOiK11391.
OMAiFHQQQVV.
OrthoDBiEOG67X1ZC.

Enzyme and pathway databases

BioCyciSENT454169:GHYG-3492-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01859. 23SrRNA_methyltr_G.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
PIRSFiPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL476.

Entry informationi

Entry nameiRLMG_SALHS
AccessioniPrimary (citable) accession number: B4TIU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: November 11, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.