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Protein

Thiamine kinase

Gene

thiK

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of thiamine to thiamine phosphate.UniRule annotation

Catalytic activityi

ATP + thiamine = ADP + thiamine phosphate.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes thiamine phosphate from thiamine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Thiamine kinase (thiK)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine phosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00596

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine kinaseUniRule annotation (EC:2.7.1.89UniRule annotation)
Gene namesi
Name:thiKUniRule annotation
Ordered Locus Names:SeHA_C1322
OrganismiSalmonella heidelberg (strain SL476)
Taxonomic identifieri454169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001980981 – 274Thiamine kinaseAdd BLAST274

Family & Domainsi

Sequence similaritiesi

Belongs to the thiamine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219316
KOiK07251
OMAiDVHAGNI

Family and domain databases

HAMAPiMF_01604 Thiamine_kinase, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR011009 Kinase-like_dom_sf
IPR014093 Thiamine_kinase
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR02721 ycfN_thiK, 1 hit

Sequencei

Sequence statusi: Complete.

B4TFI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSNNNNPLT RDEILSRYFP QYRPAVAASQ GLSGGSCIIA HDTHRVVLRR
60 70 80 90 100
HHDPDAPPAH FLRHYRALSQ LPASLAPRAL FYTPGWMAVE YLHGVVNSAL
110 120 130 140 150
PDADELAALL YHLHQQPRFG WRIALSPLLA QYWSCCDPAR RTPFWLRRLK
160 170 180 190 200
QLQKNGEPRP LRLAPLHMDV HGDNIVLTSA GLRLIDWEYA GDGDIALELA
210 220 230 240 250
AVWVEDERQH RQLADAYAAR ARIDARQLWR QIRLWHPWVI MLKAGWFEYR
260 270
WRQTGEQQFI RLADETWRQL RMKG
Length:274
Mass (Da):31,911
Last modified:September 23, 2008 - v1
Checksum:i4E29F1121639A3AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA Translation: ACF69459.1
RefSeqiWP_001257333.1, NC_011083.1

Genome annotation databases

EnsemblBacteriaiACF69459; ACF69459; SeHA_C1322
KEGGiseh:SeHA_C1322

Similar proteinsi

Entry informationi

Entry nameiTHIK_SALHS
AccessioniPrimary (citable) accession number: B4TFI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health