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B4TDY8

- RLMKL_SALHS

UniProt

B4TDY8 - RLMKL_SALHS

Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
    S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

    GO - Molecular functioni

    1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: UniProtKB-HAMAP
    3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSENT454169:GHYG-1160-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
    Including the following 2 domains:
    23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
    23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
    Gene namesi
    Name:rlmLUniRule annotation
    Ordered Locus Names:SeHA_C1170
    OrganismiSalmonella heidelberg (strain SL476)
    Taxonomic identifieri454169 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001866: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 702702Ribosomal RNA large subunit methyltransferase K/LPRO_0000366810Add
    BLAST

    Proteomic databases

    PRIDEiB4TDY8.

    Interactioni

    Protein-protein interaction databases

    STRINGi454169.SeHA_C1170.

    Structurei

    3D structure databases

    ProteinModelPortaliB4TDY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 154112THUMPUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
    Contains 1 THUMP domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0116.
    HOGENOMiHOG000218371.
    OMAiNKRGFKM.
    OrthoDBiEOG6HJ238.

    Family and domain databases

    Gene3Di3.40.50.150. 3 hits.
    HAMAPiMF_01858. 23SrRNA_methyltr_KL.
    InterProiIPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view]
    PfamiPF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    PRINTSiPR00507. N12N6MTFRASE.
    SMARTiSM00981. THUMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4TDY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSLFASTAR GLEELLKTEL EKLGAVGCQV VQGGVHFQGD TRLIYQSLMW    50
    SRLASRIILP MGECKVYSDL DLYLGVQAIN WTEIFNPGAT FAVHFSGLND 100
    TIRNSQYGAM KVKDAIVDAF TRKNLPRPNV DRESPDLRIN VWLNKETASI 150
    ALDLSGDGLH LRGYRDRTGL APIKETLAAA IVMRSGWQPG TPLLDPMCGS 200
    GTLLIEAAMW ATDRAPGLHR GHWGFSGWAQ HDETIWQEVK AEAQTRARKG 250
    LAEYSSHFYG SDSDARVIER ARSNARRAGI GELITFEVKD VAQLSNPLPK 300
    GPYGTVISNP PYGERLDSEP ALIALHSLLG RTMKNQFGGW NLSLFSASPD 350
    LLGSLQLRAD KQFKAKNGPL DCVQKNYHIA ETTADSKPAT VAEDYANRLR 400
    KNLKKLEKWA RQEGIECYRL YDADLPEYNV AVDRYGDWAV IQEYAPPKTV 450
    DAQKARQRLF DIIAATLSVL GIPPNKLVLK TRERQKGKNQ YQKMSEKGEF 500
    LEVSEYNARL WVNLTDYLDT GLFLDHRIAR RMLGEMSKGK DFLNLFSYTG 550
    SASVHAGLGG ARSTTTVDMS RTYLEWAERN LRLNGLSGRA HRLIQADCLG 600
    WLREANEQFD LIFIDPPTFS NSKRMEESFD VQRDHVALMK DLKRLLRKGG 650
    TIMFSNNKRG FRMDLEGLAE LGLTAQEITQ KTLSPDFARN RQIHNCWLIR 700
    AA 702
    Length:702
    Mass (Da):78,849
    Last modified:September 23, 2008 - v1
    Checksum:i031E82BCA744E152
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001120 Genomic DNA. Translation: ACF69678.1.
    RefSeqiYP_002045063.1. NC_011083.1.

    Genome annotation databases

    EnsemblBacteriaiACF69678; ACF69678; SeHA_C1170.
    PATRICi18510082. VBISalEnt43179_1152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001120 Genomic DNA. Translation: ACF69678.1 .
    RefSeqi YP_002045063.1. NC_011083.1.

    3D structure databases

    ProteinModelPortali B4TDY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 454169.SeHA_C1170.

    Proteomic databases

    PRIDEi B4TDY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF69678 ; ACF69678 ; SeHA_C1170 .
    PATRICi 18510082. VBISalEnt43179_1152.

    Phylogenomic databases

    eggNOGi COG0116.
    HOGENOMi HOG000218371.
    OMAi NKRGFKM.
    OrthoDBi EOG6HJ238.

    Enzyme and pathway databases

    BioCyci SENT454169:GHYG-1160-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 3 hits.
    HAMAPi MF_01858. 23SrRNA_methyltr_KL.
    InterProi IPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view ]
    Pfami PF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    PRINTSi PR00507. N12N6MTFRASE.
    SMARTi SM00981. THUMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SL476.

    Entry informationi

    Entry nameiRLMKL_SALHS
    AccessioniPrimary (citable) accession number: B4TDY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3