Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B4TB12

- GPPA_SALHS

UniProt

B4TB12 - GPPA_SALHS

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSENT454169:GHYG-4216-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:SeHA_C4243
    OrganismiSalmonella heidelberg (strain SL476)
    Taxonomic identifieri454169 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001866: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000192536Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi454169.SeHA_C4243.

    Structurei

    3D structure databases

    ProteinModelPortaliB4TB12.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4TB12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSTSLYAAI DLGSNSFHML VVREAAGSIQ TLTRIKRKVR LAAGLNNDNH    50
    LSAEAMERGW QCLRLFAERL QDIPQPQIRV VATATLRLAV NAGEFIAKAQ 100
    TILGCPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG 150
    AQTTSLFSLS MGCVTWLERY FSDRNLAQEN FDDAEKAARD VLRPVADELR 200
    FHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE 250
    LEIEGLTLER ALVFPSGLAI LIAIFTELNI QSMTLAGGAL REGLVYGMLH 300
    LAVDQDIRSR TLRNIQRRFI VDTEQANRVA KLADNFLKQV ENAWHIEPIS 350
    RELLLSACQL HEIGLSVDFK QAPYHAAYLV RHLDLPGYTP AQKKLLATLL 400
    LNQTNPVDLS SLHQQNAVPP RVAEQLCRLL RLAILFAGRR RDDLVPEITL 450
    QALNENLTLT LPGDWLAHHP LGKELIDQES QWQSYVHWPL DVR 493
    Length:493
    Mass (Da):54,830
    Last modified:September 23, 2008 - v1
    Checksum:iEFFD6C09376D2BF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001120 Genomic DNA. Translation: ACF67851.1.
    RefSeqiYP_002047934.1. NC_011083.1.

    Genome annotation databases

    EnsemblBacteriaiACF67851; ACF67851; SeHA_C4243.
    PATRICi18515944. VBISalEnt43179_4033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001120 Genomic DNA. Translation: ACF67851.1 .
    RefSeqi YP_002047934.1. NC_011083.1.

    3D structure databases

    ProteinModelPortali B4TB12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 454169.SeHA_C4243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF67851 ; ACF67851 ; SeHA_C4243 .
    PATRICi 18515944. VBISalEnt43179_4033.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci SENT454169:GHYG-4216-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SL476.

    Entry informationi

    Entry nameiGPPA_SALHS
    AccessioniPrimary (citable) accession number: B4TB12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3