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Protein

Small heat shock protein IbpB

Gene

ibpB

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Small heat shock protein IbpBUniRule annotation
Alternative name(s):
16 kDa heat shock protein BUniRule annotation
Gene namesi
Name:ibpBUniRule annotation
Ordered Locus Names:SeHA_C4139
OrganismiSalmonella heidelberg (strain SL476)
Taxonomic identifieri454169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001891091 – 142Small heat shock protein IbpBAdd BLAST142

Interactioni

Subunit structurei

Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4TA60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.UniRule annotation

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251750.
KOiK04081.
OMAiKESEYLH.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
HAMAPiMF_02001. HSP20_IbpB. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
IPR022848. HSP20_IbpB.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4TA60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNYDLSPLL RQWIGFDKLA NALQNSGESQ SFPPYNIEKS DDNHYRITLA
60 70 80 90 100
LAGFRQEDLD IQLEGTRLTV KGTPEQPENE PKWLHQGLVM QPFSLSFTLA
110 120 130 140
ENMEVSGATF TNGLLHIDLT RNEPETIAPQ RIAINERSAL NS
Length:142
Mass (Da):16,084
Last modified:September 23, 2008 - v1
Checksum:i6F7375C7CB2AE157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF68929.1.
RefSeqiWP_001246919.1. NC_011083.1.

Genome annotation databases

EnsemblBacteriaiACF68929; ACF68929; SeHA_C4139.
KEGGiseh:SeHA_C4139.
PATRICi18515740. VBISalEnt43179_3937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF68929.1.
RefSeqiWP_001246919.1. NC_011083.1.

3D structure databases

ProteinModelPortaliB4TA60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF68929; ACF68929; SeHA_C4139.
KEGGiseh:SeHA_C4139.
PATRICi18515740. VBISalEnt43179_3937.

Phylogenomic databases

HOGENOMiHOG000251750.
KOiK04081.
OMAiKESEYLH.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
HAMAPiMF_02001. HSP20_IbpB. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
IPR022848. HSP20_IbpB.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBPB_SALHS
AccessioniPrimary (citable) accession number: B4TA60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.