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Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Salmonella heidelberg (strain SL476)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: D-glycero-D-manno-heptose 7-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoheptose isomerase (gmhA)
This subpathway is part of the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate, the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611ZincUniRule annotation
Metal bindingi65 – 651ZincUniRule annotation
Binding sitei65 – 651SubstrateUniRule annotation
Binding sitei124 – 1241SubstrateUniRule annotation
Metal bindingi172 – 1721ZincUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT454169:GHYG-344-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
Alternative name(s):
Sedoheptulose 7-phosphate isomeraseUniRule annotation
Gene namesi
Name:gmhAUniRule annotation
Ordered Locus Names:SeHA_C0351
OrganismiSalmonella heidelberg (strain SL476)
Taxonomic identifieri454169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Phosphoheptose isomerasePRO_1000092290Add
BLAST

Proteomic databases

PRIDEiB4T7P3.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4T7P3.
SMRiB4T7P3. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 192156SISUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate bindingUniRule annotation
Regioni93 – 942Substrate bindingUniRule annotation
Regioni119 – 1213Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.UniRule annotation
Contains 1 SIS domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000237571.
KOiK03271.
OMAiEMHILMI.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4T7P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQDLIRNEL NEAAETLANF LKDDANIHAI QRAAVLLADS FKAGGKVLSC
60 70 80 90 100
GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHISC VSNDFGYDYI
110 120 130 140 150
FSRYVEAVGR EGDVLLGIST SGNSGNVIKA IAAAREKGMK VITLTGKDGG
160 170 180 190
KMAGTADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM VK
Length:192
Mass (Da):20,896
Last modified:September 23, 2008 - v1
Checksum:i0ABBFCCBCD6786A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF70447.1.
RefSeqiWP_000284051.1. NC_011083.1.

Genome annotation databases

EnsemblBacteriaiACF70447; ACF70447; SeHA_C0351.
KEGGiseh:SeHA_C0351.
PATRICi18508544. VBISalEnt43179_0397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001120 Genomic DNA. Translation: ACF70447.1.
RefSeqiWP_000284051.1. NC_011083.1.

3D structure databases

ProteinModelPortaliB4T7P3.
SMRiB4T7P3. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4T7P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF70447; ACF70447; SeHA_C0351.
KEGGiseh:SeHA_C0351.
PATRICi18508544. VBISalEnt43179_0397.

Phylogenomic databases

HOGENOMiHOG000237571.
KOiK03271.
OMAiEMHILMI.
OrthoDBiEOG6384PC.

Enzyme and pathway databases

UniPathwayiUPA00041; UER00436.
BioCyciSENT454169:GHYG-344-MONOMER.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL476.

Entry informationi

Entry nameiGMHA_SALHS
AccessioniPrimary (citable) accession number: B4T7P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: November 11, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.