Reviewed, UniProtKB/Swiss-Prot B4T3Z6 (ASTD_SALNS)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	SNSL254_A1417

Organism

Salmonella newport (strain SL254) [Complete proteome] [HAMAP]

Taxonomic identifier

423368 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella newport

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000138058
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4T3Z6-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: A25F5910E4974020	FASTA	492	53,192
	10 20 30 40 50 60 MTLWINGDWI TGQGERRRKT NPVSAEILWQ GNDANAAQVA EACQAARAAF PRWTREPFAA 70 80 90 100 110 120 RQAIVEKFAA LLEAHKAELT EVIARETGKP RWEAETEVTA MINKIAISIK AYHARTGEQK 130 140 150 160 170 180 SELVDGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLIFKPS ELTPWTGETV 190 200 210 220 230 240 IKLWERAGLP AGVLNLVQGG RETGQALSSL DDLDGLLFTG SASTGYQLHR QLSGQPEKIL 250 260 270 280 290 300 ALEMGGNNPL IIEDVANIDA AVHLTLQSAF ITAGQRCTCA RRLLVKQGAQ GDAFLARLVD 310 320 330 340 350 360 VAGRLQPGRW DDDPQPFIGG LISAQAAQHV MEAWRQREAL GGRTLLAPRK VKEGTSLLTP 370 380 390 400 410 420 GIIELTGVAD VPDEEVFGPL LNVWRYAHFD EAIRLANNTR FGLSCGLVST DRAQFEQLLL 430 440 450 460 470 480 EARAGIVNWN KPLTGAASTA PFGGVGASGN HRPSAWYAAD YCAWPMASLE SPELTLPATL 490 SPGLDFSRRE AV

References

[1]	"Complete genome of Salmonella newport strain SL254." Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., Leclerc J., Cebula T., Sebastian Y. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001113 Genomic DNA. Translation: ACF64167.1.
RefSeq	YP_002040563.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6484641.
GenomeReviews	Gene locus SNSL254_A1417 in contig CP001113_GR.
KEGG	see:SNSL254_A1417.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KAYHART.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_SALNS

Accession

Primary (citable) accession number: B4T3Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)