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B4T3Q8

- NAGK_SALNS

UniProt

B4T3Q8 - NAGK_SALNS

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Salmonella newport (strain SL254)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi179 – 1791ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSENT423368:GHJB-1309-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:SNSL254_A1320
    OrganismiSalmonella newport (strain SL254)
    Taxonomic identifieri423368 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008824: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_1000140195Add
    BLAST

    Proteomic databases

    PRIDEiB4T3Q8.

    Interactioni

    Protein-protein interaction databases

    STRINGi423368.SNSL254_A1320.

    Structurei

    3D structure databases

    ProteinModelPortaliB4T3Q8.
    SMRiB4T3Q8. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    OMAiMESINES.
    OrthoDBiEOG61P6P0.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4T3Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDIGGT KIALGVFDST RRLQWEKRVP TPHTSYSAFL DAVCELVEEA    50
    DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV 100
    RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVL NGKPITGQSY 150
    ITGEFGHMRL PVDALTLMGF DFPLRRCGCG QMGCIENYLS GRGFAWLYQH 200
    YYDQSLQAPE IIALWEQGDE QAHAHVERYL DLLAVCLGNI LTIVDPDLLV 250
    IGGGLSNFTA ITTQLAERLP RHLLPVARAP RIERARHGDA GGMRGAAFLH 300
    LTD 303
    Length:303
    Mass (Da):33,060
    Last modified:September 23, 2008 - v1
    Checksum:i3BF0B7587DDAA469
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001113 Genomic DNA. Translation: ACF62384.1.
    RefSeqiYP_002040475.1. NC_011080.1.

    Genome annotation databases

    EnsemblBacteriaiACF62384; ACF62384; SNSL254_A1320.
    PATRICi18521060. VBISalEnt114557_1433.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001113 Genomic DNA. Translation: ACF62384.1 .
    RefSeqi YP_002040475.1. NC_011080.1.

    3D structure databases

    ProteinModelPortali B4T3Q8.
    SMRi B4T3Q8. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 423368.SNSL254_A1320.

    Proteomic databases

    PRIDEi B4T3Q8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF62384 ; ACF62384 ; SNSL254_A1320 .
    PATRICi 18521060. VBISalEnt114557_1433.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    OMAi MESINES.
    OrthoDBi EOG61P6P0.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci SENT423368:GHJB-1309-MONOMER.

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SL254.

    Entry informationi

    Entry nameiNAGK_SALNS
    AccessioniPrimary (citable) accession number: B4T3Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3