accD

Functionⁱ

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO₂ group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityⁱ

ATP + acetyl-CoA + HCO₃^- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactorⁱ

Zn²⁺UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayⁱ: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)

This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	27	ZincUniRule annotation	1
Metal bindingⁱ	30	ZincUniRule annotation	1
Metal bindingⁱ	46	ZincUniRule annotation	1
Metal bindingⁱ	49	ZincUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	27 – 49	C4-typeUniRule annotationAdd BLAST		23

GO - Molecular functionⁱ

acetyl-CoA carboxylase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid biosynthetic process Source: UniProtKB-KW
malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayⁱ	UPA00655; UER00711.

UniPathwayⁱ

UPA00655; UER00711.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation (EC:6.4.1.2UniRule annotation) Short name: ACCase subunit betaUniRule annotation Short name: Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesⁱ	Name:accDUniRule annotation Ordered Locus Names:SNSL254_A2554
Organismⁱ	Salmonella newport (strain SL254)
Taxonomic identifierⁱ	423368 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella newport
Proteomesⁱ	UP000008824 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01395

GO - Cellular componentⁱ

acetyl-CoA carboxylase complex Source: InterPro

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000359055	1 – 304	Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST		304

Interactionⁱ

Subunit structureⁱ

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B4SZN8.
SMRⁱ	B4SZN8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 292	CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST		270

Sequence similaritiesⁱ

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	27 – 49	C4-typeUniRule annotationAdd BLAST		23

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

HOGENOMⁱ	HOG000021670.
KEGG Orthology (KO) More...KOⁱ	K01963.
OMAⁱ	PEGLWIK.

Family and domain databases

HAMAPⁱ	MF_01395. AcetylCoA_CT_beta. 1 hit.
InterProⁱ	View protein in InterPro IPR034733. AcCoA_carboxyl. IPR000438. Acetyl_CoA_COase_Trfase_b_su. IPR029045. ClpP/crotonase-like_dom_sf. IPR011762. COA_CT_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01039. Carboxyl_trans. 1 hit.
PRINTSⁱ	PR01070. ACCCTRFRASEB.
SUPFAMⁱ	SSF52096. SSF52096. 1 hit.
TIGRFAMsⁱ	TIGR00515. accD. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50980. COA_CT_NTER. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B4SZN8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSWIERIKSN ITPTRKASIP EGVWTKCDSC GQVLYRAELE RNLEVCPKCD 
        60         70         80         90        100
HHMRMSARNR LHSLLDEGSL VELGSELEPK DVLKFRDSKK YKDRLASAQK 
       110        120        130        140        150
ETGEKDALVV MKGTLHGMPV VAAAFEFAFM GGSMGSVVGA RFVRAVEQAL 
       160        170        180        190        200
EDNCPLVCFS ASGGARMQEA LMSLMQMAKT SAALAKMQER GLPYISVLTD 
       210        220        230        240        250
PTMGGVSASF AMLGDLNIAE PKALIGFAGP RVIEQTVREK LPPGFQRSEF 
       260        270        280        290        300
LIEKGAIDMI VRRPEMRLKL ASILAKLMNL PAPNPDAPRE GVVVPPAPDQ 

ESEA

Length:304

Mass (Da):33,216

Last modified:September 23, 2008 - v1

Checksum:ⁱA065AE6282B094AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001113 Genomic DNA. Translation: ACF61424.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_000118383.1. NZ_CCMR01000001.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACF61424; ACF61424; SNSL254_A2554.
KEGGⁱ	see:SNSL254_A2554.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B4SZN8	B5EZQ0 Q57LY8 B5FPL0 B5R347 B5RCJ1 B4TBN5 A9N478 B4TQA2 Q8XFJ5 Q7CQ41 +74	Salmonella agona (strain SL483) Salmonella choleraesuis (strain SC-B67) Salmonella dublin (strain CT_02021853) Salmonella enteritidis PT4 (strain P125109) Salmonella gallinarum (strain 287/91 / NCTC 13346) Salmonella heidelberg (strain SL476) Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) Salmonella schwarzengrund (strain CVM19633) Salmonella typhi Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) And more	304	UniRef100_B5EZQ0	Cluster: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	85

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B4SZN8	A9MJ59 A0A221ZJT6 G8LLJ0 W0BM16 A0A2J5TVJ1 A0A1X3L1H3 UPI000246EF1D K8A7W2 A0A0K2PAU7 UPI0006ACF50D +818	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) Salmonella enterica I Enterobacter cloacae EcWSU1 Enterobacter cloacae P101 Klebsiella pneumoniae Escherichia coli H420 Escherichia coli Cronobacter muytjensii 530 Cronobacter muytjensii ATCC 51329 Cronobacter muytjensii And more	304	UniRef90_A9MJ59	Cluster: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	829

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B4SZN8	A9MJ59 A0A221ZJT6 G8LLJ0 W0BM16 A0A2J5TVJ1 A0A1X3L1H3 UPI000246EF1D K8A7W2 A0A0K2PAU7 UPI0006ACF50D +896	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) Salmonella enterica I Enterobacter cloacae EcWSU1 Enterobacter cloacae P101 Klebsiella pneumoniae Escherichia coli H420 Escherichia coli Cronobacter muytjensii 530 Cronobacter muytjensii ATCC 51329 Cronobacter muytjensii And more	304	UniRef50_A9MJ59	Cluster: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	907

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001113 Genomic DNA. Translation: ACF61424.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_000118383.1. NZ_CCMR01000001.1.

3D structure databases

ProteinModelPortalⁱ	B4SZN8.
SMRⁱ	B4SZN8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACF61424; ACF61424; SNSL254_A2554.
KEGGⁱ	see:SNSL254_A2554.

Phylogenomic databases

HOGENOMⁱ	HOG000021670.
KEGG Orthology (KO) More...KOⁱ	K01963.
OMAⁱ	PEGLWIK.

Enzyme and pathway databases

UniPathwayⁱ	UPA00655; UER00711.

UniPathwayⁱ

UPA00655; UER00711.

Family and domain databases

HAMAPⁱ	MF_01395. AcetylCoA_CT_beta. 1 hit.
InterProⁱ	View protein in InterPro IPR034733. AcCoA_carboxyl. IPR000438. Acetyl_CoA_COase_Trfase_b_su. IPR029045. ClpP/crotonase-like_dom_sf. IPR011762. COA_CT_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01039. Carboxyl_trans. 1 hit.
PRINTSⁱ	PR01070. ACCCTRFRASEB.
SUPFAMⁱ	SSF52096. SSF52096. 1 hit.
TIGRFAMsⁱ	TIGR00515. accD. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50980. COA_CT_NTER. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACCD_SALNS
Accessionⁱ	B4SZN8Primary (citable) accession number: B4SZN8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
	Last sequence update:	September 23, 2008
	Last modified:	November 22, 2017
	This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B4SZN8 (ACCD_SALNS)

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Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: malonyl-CoA biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: malonyl-CoA biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ