true2009-07-282024-03-2796FADB_SALNSComparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution.Fricke W.F.Mammel M.K.McDermott P.F.Tartera C.White D.G.Leclerc J.E.Ravel J.Cebula T.A.doi:10.1128/jb.00297-112011J. Bacteriol.1933556-3568NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]SL254crotonase-likeNAD(P)-binding Rossmann-like DomainFadB3-OHacyl-CoA_DH_CS3-OHacyl-CoA_DH_NAD-bd3HC_DH_C6-PGluconate_DH-like_C_sfClpP/crotonase-like_dom_sfEnoyl-CoA_hyd/isom_CSEnoyl-CoA_hydra/isoFadBNAD(P)-bd_dom_sfFadBFATTY ACID OXIDATION COMPLEX SUBUNIT ALPHATRIFUNCTIONAL ENZYME SUBUNIT ALPHA3HCDH3HCDH_NECH_16-phosphogluconate dehydrogenase C-terminal domain-likeClpP/crotonaseNAD(P)-binding Rossmann-fold domains3HCDHENOYL_COA_HYDRATASEFatty acid oxidation complex subunit alphaEnoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase4.2.1.175.1.2.35.3.3.83-hydroxyacyl-CoA dehydrogenase1.1.1.35fadBSNSL254_A4262Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Fatty acid oxidation complex subunit alpha795431729Enoyl-CoA hydratase/isomerase1893-hydroxyacyl-CoA dehydrogenase311Disordered708For 3-hydroxyacyl-CoA dehydrogenase activity450296324343400402407429453500660Important for catalytic activity119Important for catalytic activity139substrate2008-09-23179543ff3fcdf1caaf82bdd382694b19c151cbMLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRMLGADSALEIIAAGKDVGAEHALKIGLVDGVVKQETLIEGAIAVLRQAITGDLDWRAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPMTAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDIETPKQAAVLGAGIMGGGIAYQSAWKGVPVIMKDINDKSLNLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGELASALEHPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKEYRDAIDALFDASRFGQKNGLGFWRYKEDSKGKPKKEEDAAVDDLLASVSQPKHDFSDDEIIARMMIPMINEVVRCLEEGIIASPAEADMALVYGLGFPPFHGGAFRWLDTQGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGSLKTAtrue