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Protein

Acetyl esterase

Gene

aes

Organism
Salmonella newport (strain SL254)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651UniRule annotation
Active sitei262 – 2621UniRule annotation
Active sitei292 – 2921UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciSENT423368:GHJB-533-MONOMER.

Protein family/group databases

ESTHERisalty-AES. Hormone-sensitive_lipase_like_1.
MEROPSiS09.A47.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl esteraseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:aesUniRule annotation
Ordered Locus Names:SNSL254_A0542
OrganismiSalmonella newport (strain SL254)
Taxonomic identifieri423368 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008824 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Acetyl esterasePRO_1000188993Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with MalT and MelA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4SWY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi91 – 933Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000117644.
KOiK01066.
OMAiRMMESAD.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01958. Acetyl_esterase. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR023508. Acetyl_esterase.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4SWY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPENKIPVL TRLSDEMKAV VNFQQPGLPP WPADGDIETQ RQYYLLERRF
60 70 80 90 100
WNADAPSMTT RTCAVPTPYG DVTTRLYSPQ PTSQATLYYL HGGGFILGNL
110 120 130 140 150
DTHDRIMRLL ARYTGCTVIG IDYSLSPQAR YPQAIEETVA VCSYFSQHAD
160 170 180 190 200
EYSLNVEKIG FAGDSAGAML ALASALWLRD KHIRCGNVIA ILLWYGLYGL
210 220 230 240 250
QDSVSRRLFG GAWDGLTRED LDMYEKAYLR NDEDRESPWY CLFNNDLTRD
260 270 280 290 300
VPPCFIASAE FDPLIDDSRL LHQTLQAHQQ PCEYKMYPGT LHAFLHYSRM
310 320
MTIADDALQD GARFFMARMK TPR
Length:323
Mass (Da):36,826
Last modified:September 23, 2008 - v1
Checksum:i6C31BD12AF909E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001113 Genomic DNA. Translation: ACF64907.1.
RefSeqiWP_000801778.1. NZ_CCMR01000003.1.

Genome annotation databases

EnsemblBacteriaiACF64907; ACF64907; SNSL254_A0542.
KEGGisee:SNSL254_A0542.
PATRICi18519514. VBISalEnt114557_0676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001113 Genomic DNA. Translation: ACF64907.1.
RefSeqiWP_000801778.1. NZ_CCMR01000003.1.

3D structure databases

ProteinModelPortaliB4SWY4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERisalty-AES. Hormone-sensitive_lipase_like_1.
MEROPSiS09.A47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF64907; ACF64907; SNSL254_A0542.
KEGGisee:SNSL254_A0542.
PATRICi18519514. VBISalEnt114557_0676.

Phylogenomic databases

HOGENOMiHOG000117644.
KOiK01066.
OMAiRMMESAD.

Enzyme and pathway databases

BioCyciSENT423368:GHJB-533-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01958. Acetyl_esterase. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR023508. Acetyl_esterase.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAES_SALNS
AccessioniPrimary (citable) accession number: B4SWY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.