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Protein

Acetyl esterase

Gene

aes

Organism
Salmonella newport (strain SL254)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165UniRule annotation1
Active sitei262UniRule annotation1
Active sitei292UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERisalty-AES Hormone-sensitive_lipase_like

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl esteraseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:aesUniRule annotation
Ordered Locus Names:SNSL254_A0542
OrganismiSalmonella newport (strain SL254)
Taxonomic identifieri423368 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008824 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001889931 – 323Acetyl esteraseAdd BLAST323

Proteomic databases

PRIDEiB4SWY4

Interactioni

Subunit structurei

Homodimer. Interacts with MalT and MelA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4SWY4
SMRiB4SWY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 93Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000117644
KOiK01066
OMAiGIIGMNS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_01958 Acetyl_esterase, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR023508 Acetyl_esterase
IPR033140 Lipase_GDXG_put_SER_AS
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01174 LIPASE_GDXG_SER, 1 hit

Sequencei

Sequence statusi: Complete.

B4SWY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPENKIPVL TRLSDEMKAV VNFQQPGLPP WPADGDIETQ RQYYLLERRF
60 70 80 90 100
WNADAPSMTT RTCAVPTPYG DVTTRLYSPQ PTSQATLYYL HGGGFILGNL
110 120 130 140 150
DTHDRIMRLL ARYTGCTVIG IDYSLSPQAR YPQAIEETVA VCSYFSQHAD
160 170 180 190 200
EYSLNVEKIG FAGDSAGAML ALASALWLRD KHIRCGNVIA ILLWYGLYGL
210 220 230 240 250
QDSVSRRLFG GAWDGLTRED LDMYEKAYLR NDEDRESPWY CLFNNDLTRD
260 270 280 290 300
VPPCFIASAE FDPLIDDSRL LHQTLQAHQQ PCEYKMYPGT LHAFLHYSRM
310 320
MTIADDALQD GARFFMARMK TPR
Length:323
Mass (Da):36,826
Last modified:September 23, 2008 - v1
Checksum:i6C31BD12AF909E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001113 Genomic DNA Translation: ACF64907.1
RefSeqiWP_000801778.1, NZ_CCMR01000003.1

Genome annotation databases

EnsemblBacteriaiACF64907; ACF64907; SNSL254_A0542
KEGGisee:SNSL254_A0542

Similar proteinsi

Entry informationi

Entry nameiAES_SALNS
AccessioniPrimary (citable) accession number: B4SWY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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