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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911SubstrateUniRule annotation
Active sitei100 – 1001Proton acceptorUniRule annotation
Binding sitei122 – 1221ATPUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-234-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:Smal_0234
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
Proteomesi
  • UP000001867 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Type III pantothenate kinasePRO_1000140257Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi391008.Smal_0234.

Structurei

3D structure databases

ProteinModelPortaliB4ST96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 1014Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066026.
KOiK03525.
OMAiFIKWRVI.
OrthoDBiEOG6G20K0.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

B4ST96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDWLFDLGN SRFKFAPLQG DRAGDVQAWA HGAEGMAGQP PHSLPSGTTA
60 70 80 90 100
FVASVAAPSL TSAMLDQLQR RFEHVHVVRT SAECAGVRIA YAKPEKFGVD
110 120 130 140 150
RFLALLAAAK AQRPVLVVGV GTALTIDLLD ANGQHHGGRI SASPTTMREA
160 170 180 190 200
LHARAVQLPA TGGDYSEFAN DTADALASGC DGAAVALIER SAQQAHALLG
210 220 230 240
VAPSLLVHGG GAPALMPLLP GADYHPSLVL DGLARWAVHQ PAG
Length:243
Mass (Da):25,158
Last modified:September 23, 2008 - v1
Checksum:i68ACA1BE7B46AE49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001111 Genomic DNA. Translation: ACF49939.1.
RefSeqiWP_012509777.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF49939; ACF49939; Smal_0234.
KEGGismt:Smal_0234.
PATRICi23705268. VBISteMal40512_0238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001111 Genomic DNA. Translation: ACF49939.1.
RefSeqiWP_012509777.1. NC_011071.1.

3D structure databases

ProteinModelPortaliB4ST96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391008.Smal_0234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF49939; ACF49939; Smal_0234.
KEGGismt:Smal_0234.
PATRICi23705268. VBISteMal40512_0238.

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066026.
KOiK03525.
OMAiFIKWRVI.
OrthoDBiEOG6G20K0.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciSMAL391008:GH1H-234-MONOMER.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiCOAX_STRM5
AccessioniPrimary (citable) accession number: B4ST96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 11, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.