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B4SS67

- GCSP_STRM5

UniProt

B4SS67 - GCSP_STRM5

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Smal_3000
Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-3071-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Smal_3000
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000001867: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000132459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi391008.Smal_3000.

Structurei

3D structure databases

ProteinModelPortaliB4SS67.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiERRDICL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B4SS67-1 [UniParc]FASTAAdd to Basket

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MSQNTPSLRE LEHHSAFVER HIGPNDAEIA QMLGVIGHAS LDAMTDAIVP    50
AKIKSPAPLA LPESITEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV 100
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMEIANASL 150
LDEATAAAEA MTLAKRSAKS KSDTFFVHDA VHPQTLELLR TRAEPMGIVL 200
RVGTPAEALE ADSFGLLLQY PDTFGQVGDY KALVDAVHAR GGLVAVATDL 250
LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 300
RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA 350
VYHGPEGLTR IARRTHRLAS ILAAALRKAG VQVGGDFFDT LHVTGVHAEE 400
IHAKARAAGY NLRAIDSDSV GISLDETTTR ADIVAVASVF GASLDVDALD 450
ASTADALPAG LLRQSEFLTH PVFNTHHSEH ELLRYLRSLA DKDLAMDRTM 500
IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK ELIDSLEAML 550
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEDHRD ICLIPDSAHG 600
TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST 650
HGVFEEEVVE ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL 700
HKTFCIPHGG GGPGVGPCAV KEHLAPFLPG KLGDHGPVGM VSAASFGSAS 750
ILPISWMYIA MMGTEGLRKA TQVAQLNANY IAKRLAPHFK TLYTGRNGLV 800
AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV AGTLMVEPTE 850
SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE 900
WTHAYPRELA AFPLPSLKLQ KYWPPVARVD NVYGDKNVMC ACIPVDAYKD 950
DEVEA 955
Length:955
Mass (Da):103,078
Last modified:September 23, 2008 - v1
Checksum:iCA77D3E89617341C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF52699.1.
RefSeqiYP_002029382.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF52699; ACF52699; Smal_3000.
GeneIDi6475817.
KEGGismt:Smal_3000.
PATRICi23710980. VBISteMal40512_3024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF52699.1 .
RefSeqi YP_002029382.1. NC_011071.1.

3D structure databases

ProteinModelPortali B4SS67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391008.Smal_3000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF52699 ; ACF52699 ; Smal_3000 .
GeneIDi 6475817.
KEGGi smt:Smal_3000.
PATRICi 23710980. VBISteMal40512_3024.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi ERRDICL.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SMAL391008:GH1H-3071-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiGCSP_STRM5
AccessioniPrimary (citable) accession number: B4SS67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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