B4SS67 (GCSP_STRM5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine dehydrogenase [decarboxylating]
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase

Gene names

Name:	gcvP
Ordered Locus Names:	Smal_3000

Organism

Stenotrophomonas maltophilia (strain R551-3) [Complete proteome] [HAMAP]

Taxonomic identifier

391008 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Stenotrophomonas › Stenotrophomonas maltophilia group › Stenotrophomonas maltophilia

Protein attributes

Sequence length	955 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00711
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvP family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 955	955	Glycine dehydrogenase [decarboxylating] HAMAP-Rule MF_00711		PRO_1000132459
Amino acid modifications
	Modified residue	702	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4SS67 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: CA77D3E89617341C	FASTA	955	103,078
	10 20 30 40 50 60 MSQNTPSLRE LEHHSAFVER HIGPNDAEIA QMLGVIGHAS LDAMTDAIVP AKIKSPAPLA 70 80 90 100 110 120 LPESITEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV ILRNILENPA WYTAYTPYQA 130 140 150 160 170 180 EISQGRMEAL INFQTLCADL TGMEIANASL LDEATAAAEA MTLAKRSAKS KSDTFFVHDA 190 200 210 220 230 240 VHPQTLELLR TRAEPMGIVL RVGTPAEALE ADSFGLLLQY PDTFGQVGDY KALVDAVHAR 250 260 270 280 290 300 GGLVAVATDL LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 310 320 330 340 350 360 RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA VYHGPEGLTR 370 380 390 400 410 420 IARRTHRLAS ILAAALRKAG VQVGGDFFDT LHVTGVHAEE IHAKARAAGY NLRAIDSDSV 430 440 450 460 470 480 GISLDETTTR ADIVAVASVF GASLDVDALD ASTADALPAG LLRQSEFLTH PVFNTHHSEH 490 500 510 520 530 540 ELLRYLRSLA DKDLAMDRTM IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK 550 560 570 580 590 600 ELIDSLEAML VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEDHRD ICLIPDSAHG 610 620 630 640 650 660 TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST HGVFEEEVVE 670 680 690 700 710 720 ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL HKTFCIPHGG GGPGVGPCAV 730 740 750 760 770 780 KEHLAPFLPG KLGDHGPVGM VSAASFGSAS ILPISWMYIA MMGTEGLRKA TQVAQLNANY 790 800 810 820 830 840 IAKRLAPHFK TLYTGRNGLV AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV 850 860 870 880 890 900 AGTLMVEPTE SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE 910 920 930 940 950 WTHAYPRELA AFPLPSLKLQ KYWPPVARVD NVYGDKNVMC ACIPVDAYKD DEVEA

References

[1]

"Complete sequence of Stenotrophomonas maltophilia R551-3." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Taghavi S., Monchy S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R551-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001111 Genomic DNA. Translation: ACF52699.1.
RefSeq	YP_002029382.1. NC_011071.1.
3D structure databases
ProteinModelPortal	B4SS67.
ModBase	Search...
Protein-protein interaction databases
STRING	391008.Smal_3000.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACF52699; ACF52699; Smal_3000.
GeneID	6475817.
KEGG	smt:Smal_3000.
PATRIC	23710980. VBISteMal40512_3024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1003.
HOGENOM	HOG000239369.
KO	K00281.
OMA	QTMVCDL.
ProtClustDB	PRK05367.
Enzyme and pathway databases
BioCyc	SMAL391008:GH1H-3070-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 2 hits.
HAMAP	MF_00711. GcvP.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR003437. GDC_P_homo. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 2 hits. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 2 hits.
TIGRFAMs	TIGR00461. gcvP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSP_STRM5

Accession

Primary (citable) accession number: B4SS67

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program