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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-3071-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Smal_3000
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000001867 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000132459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi391008.Smal_3000.

Structurei

3D structure databases

ProteinModelPortaliB4SS67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B4SS67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNTPSLRE LEHHSAFVER HIGPNDAEIA QMLGVIGHAS LDAMTDAIVP
60 70 80 90 100
AKIKSPAPLA LPESITEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV
110 120 130 140 150
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMEIANASL
160 170 180 190 200
LDEATAAAEA MTLAKRSAKS KSDTFFVHDA VHPQTLELLR TRAEPMGIVL
210 220 230 240 250
RVGTPAEALE ADSFGLLLQY PDTFGQVGDY KALVDAVHAR GGLVAVATDL
260 270 280 290 300
LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG
310 320 330 340 350
RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA
360 370 380 390 400
VYHGPEGLTR IARRTHRLAS ILAAALRKAG VQVGGDFFDT LHVTGVHAEE
410 420 430 440 450
IHAKARAAGY NLRAIDSDSV GISLDETTTR ADIVAVASVF GASLDVDALD
460 470 480 490 500
ASTADALPAG LLRQSEFLTH PVFNTHHSEH ELLRYLRSLA DKDLAMDRTM
510 520 530 540 550
IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK ELIDSLEAML
560 570 580 590 600
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEDHRD ICLIPDSAHG
610 620 630 640 650
TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST
660 670 680 690 700
HGVFEEEVVE ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPCAV KEHLAPFLPG KLGDHGPVGM VSAASFGSAS
760 770 780 790 800
ILPISWMYIA MMGTEGLRKA TQVAQLNANY IAKRLAPHFK TLYTGRNGLV
810 820 830 840 850
AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV AGTLMVEPTE
860 870 880 890 900
SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE
910 920 930 940 950
WTHAYPRELA AFPLPSLKLQ KYWPPVARVD NVYGDKNVMC ACIPVDAYKD

DEVEA
Length:955
Mass (Da):103,078
Last modified:September 23, 2008 - v1
Checksum:iCA77D3E89617341C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001111 Genomic DNA. Translation: ACF52699.1.
RefSeqiWP_012511825.1. NC_011071.1.
YP_002029382.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF52699; ACF52699; Smal_3000.
KEGGismt:Smal_3000.
PATRICi23710980. VBISteMal40512_3024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001111 Genomic DNA. Translation: ACF52699.1.
RefSeqiWP_012511825.1. NC_011071.1.
YP_002029382.1. NC_011071.1.

3D structure databases

ProteinModelPortaliB4SS67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391008.Smal_3000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF52699; ACF52699; Smal_3000.
KEGGismt:Smal_3000.
PATRICi23710980. VBISteMal40512_3024.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-3071-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiGCSP_STRM5
AccessioniPrimary (citable) accession number: B4SS67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 27, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.