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B4SS67

- GCSP_STRM5

UniProt

B4SS67 - GCSP_STRM5

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSMAL391008:GH1H-3071-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Smal_3000
    OrganismiStenotrophomonas maltophilia (strain R551-3)
    Taxonomic identifieri391008 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
    ProteomesiUP000001867: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000132459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi391008.Smal_3000.

    Structurei

    3D structure databases

    ProteinModelPortaliB4SS67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiERRDICL.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4SS67-1 [UniParc]FASTAAdd to Basket

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    MSQNTPSLRE LEHHSAFVER HIGPNDAEIA QMLGVIGHAS LDAMTDAIVP    50
    AKIKSPAPLA LPESITEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV 100
    ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMEIANASL 150
    LDEATAAAEA MTLAKRSAKS KSDTFFVHDA VHPQTLELLR TRAEPMGIVL 200
    RVGTPAEALE ADSFGLLLQY PDTFGQVGDY KALVDAVHAR GGLVAVATDL 250
    LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 300
    RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA 350
    VYHGPEGLTR IARRTHRLAS ILAAALRKAG VQVGGDFFDT LHVTGVHAEE 400
    IHAKARAAGY NLRAIDSDSV GISLDETTTR ADIVAVASVF GASLDVDALD 450
    ASTADALPAG LLRQSEFLTH PVFNTHHSEH ELLRYLRSLA DKDLAMDRTM 500
    IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK ELIDSLEAML 550
    VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEDHRD ICLIPDSAHG 600
    TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST 650
    HGVFEEEVVE ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL 700
    HKTFCIPHGG GGPGVGPCAV KEHLAPFLPG KLGDHGPVGM VSAASFGSAS 750
    ILPISWMYIA MMGTEGLRKA TQVAQLNANY IAKRLAPHFK TLYTGRNGLV 800
    AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV AGTLMVEPTE 850
    SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE 900
    WTHAYPRELA AFPLPSLKLQ KYWPPVARVD NVYGDKNVMC ACIPVDAYKD 950
    DEVEA 955
    Length:955
    Mass (Da):103,078
    Last modified:September 23, 2008 - v1
    Checksum:iCA77D3E89617341C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001111 Genomic DNA. Translation: ACF52699.1.
    RefSeqiYP_002029382.1. NC_011071.1.

    Genome annotation databases

    EnsemblBacteriaiACF52699; ACF52699; Smal_3000.
    GeneIDi6475817.
    KEGGismt:Smal_3000.
    PATRICi23710980. VBISteMal40512_3024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001111 Genomic DNA. Translation: ACF52699.1 .
    RefSeqi YP_002029382.1. NC_011071.1.

    3D structure databases

    ProteinModelPortali B4SS67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391008.Smal_3000.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF52699 ; ACF52699 ; Smal_3000 .
    GeneIDi 6475817.
    KEGGi smt:Smal_3000.
    PATRICi 23710980. VBISteMal40512_3024.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi ERRDICL.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SMAL391008:GH1H-3071-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R551-3.

    Entry informationi

    Entry nameiGCSP_STRM5
    AccessioniPrimary (citable) accession number: B4SS67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3