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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMAL391008:G1GCF-2994-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Smal_2912
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
Proteomesi
  • UP000001867 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913671 – 880Leucine--tRNA ligaseAdd BLAST880

Proteomic databases

PRIDEiB4SRE7

Interactioni

Protein-protein interaction databases

STRINGi391008.Smal_2912

Structurei

3D structure databases

ProteinModelPortaliB4SRE7
SMRiB4SRE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 56"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B4SRE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVEPNVYD PQQVESAAQQ YWDATRAFEV DEASDKPKYY CLSMLPYPSG
60 70 80 90 100
ALHMGHVRNY TIGDVISRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA
110 120 130 140 150
PAAWTYKNID HMRTQLKSLG YAIDWSREFA TCRPDYYVHE QRMFTRLMRK
160 170 180 190 200
GLAYRRNAVV NWDPVDQTVL ANEQVIDGRG WRSGALVEKR EIPQWFLRIT
210 220 230 240 250
DYAQELLDGL DELDGWPESV KTMQRNWIGR SEGLEIQFDV RDVDGGVLDP
260 270 280 290 300
LRVFTTRPDT VMGVTFVSIA AEHPLALHAA KNNPELAALL ADLKQGGVSE
310 320 330 340 350
AELETQEKRG MDTGLRAIHP VTGEQVPVWV ANFVLMGYGT GAVMAVPGHD
360 370 380 390 400
QRDNEVANKY GLPIVQVIAL KDPRSEEERS WDATRWQDWY SDKSRAFELV
410 420 430 440 450
NSAEFDGLDF QGAFEALAER FERKAQGQRR VNYRLRDWGV SRQRYWGCPI
460 470 480 490 500
PVIYCAKCGA VPVPEEQLPV VLPEDVAFAG TGSPIKTDPE WRKTTCPECG
510 520 530 540 550
GAAERETDTF DTFMESSWYY ARYTSPGARD AVDKRGNYWL PVDQYIGGIE
560 570 580 590 600
HAILHLMYFR FYHKLLRDAR MVDSNEPARN LLCQGMVIAE TYYRPNPDGS
610 620 630 640 650
RDWINPADVD VQRDERGRIT GATLIADGQP VVVGGTEKMS KSKNNGVDPQ
660 670 680 690 700
AMVGKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFLR RLWAQVQKHA
710 720 730 740 750
ADGAAPALDV AVLDASQKAL RRKTHETIGK VGDDYGRRHS FNTAIAAVME
760 770 780 790 800
LMNALAKFDD GSDQGRAVRQ EALQAIVLLL NPITPHASHT LWQVLGHGET
810 820 830 840 850
LLEDQPFPQA DAAALVRDAL TLAVQVNGKL RGTIEVAADA PREQVEALAL
860 870 880
AEPNAAKFME GLTVRKIIIV PGKIVNIVVA
Length:880
Mass (Da):98,368
Last modified:September 23, 2008 - v1
Checksum:i2E51014105B0163A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001111 Genomic DNA Translation: ACF52611.1
RefSeqiWP_012511768.1, NC_011071.1

Genome annotation databases

EnsemblBacteriaiACF52611; ACF52611; Smal_2912
KEGGismt:Smal_2912

Similar proteinsi

Entry informationi

Entry nameiSYL_STRM5
AccessioniPrimary (citable) accession number: B4SRE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health