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B4SRE7

- SYL_STRM5

UniProt

B4SRE7 - SYL_STRM5

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Protein
Leucine--tRNA ligase
Gene
leuS, Smal_2912
Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-2983-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Smal_2912
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000001867: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Leucine--tRNA ligaseUniRule annotation
PRO_1000091367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391008.Smal_2912.

Structurei

3D structure databases

ProteinModelPortaliB4SRE7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionUniRule annotation
Add
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4SRE7-1 [UniParc]FASTAAdd to Basket

« Hide

MTSVEPNVYD PQQVESAAQQ YWDATRAFEV DEASDKPKYY CLSMLPYPSG    50
ALHMGHVRNY TIGDVISRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA 100
PAAWTYKNID HMRTQLKSLG YAIDWSREFA TCRPDYYVHE QRMFTRLMRK 150
GLAYRRNAVV NWDPVDQTVL ANEQVIDGRG WRSGALVEKR EIPQWFLRIT 200
DYAQELLDGL DELDGWPESV KTMQRNWIGR SEGLEIQFDV RDVDGGVLDP 250
LRVFTTRPDT VMGVTFVSIA AEHPLALHAA KNNPELAALL ADLKQGGVSE 300
AELETQEKRG MDTGLRAIHP VTGEQVPVWV ANFVLMGYGT GAVMAVPGHD 350
QRDNEVANKY GLPIVQVIAL KDPRSEEERS WDATRWQDWY SDKSRAFELV 400
NSAEFDGLDF QGAFEALAER FERKAQGQRR VNYRLRDWGV SRQRYWGCPI 450
PVIYCAKCGA VPVPEEQLPV VLPEDVAFAG TGSPIKTDPE WRKTTCPECG 500
GAAERETDTF DTFMESSWYY ARYTSPGARD AVDKRGNYWL PVDQYIGGIE 550
HAILHLMYFR FYHKLLRDAR MVDSNEPARN LLCQGMVIAE TYYRPNPDGS 600
RDWINPADVD VQRDERGRIT GATLIADGQP VVVGGTEKMS KSKNNGVDPQ 650
AMVGKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFLR RLWAQVQKHA 700
ADGAAPALDV AVLDASQKAL RRKTHETIGK VGDDYGRRHS FNTAIAAVME 750
LMNALAKFDD GSDQGRAVRQ EALQAIVLLL NPITPHASHT LWQVLGHGET 800
LLEDQPFPQA DAAALVRDAL TLAVQVNGKL RGTIEVAADA PREQVEALAL 850
AEPNAAKFME GLTVRKIIIV PGKIVNIVVA 880
Length:880
Mass (Da):98,368
Last modified:September 23, 2008 - v1
Checksum:i2E51014105B0163A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF52611.1.
RefSeqiWP_012511768.1. NC_011071.1.
YP_002029294.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF52611; ACF52611; Smal_2912.
GeneIDi6475659.
KEGGismt:Smal_2912.
PATRICi23710796. VBISteMal40512_2932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF52611.1 .
RefSeqi WP_012511768.1. NC_011071.1.
YP_002029294.1. NC_011071.1.

3D structure databases

ProteinModelPortali B4SRE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391008.Smal_2912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF52611 ; ACF52611 ; Smal_2912 .
GeneIDi 6475659.
KEGGi smt:Smal_2912.
PATRICi 23710796. VBISteMal40512_2932.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SMAL391008:GH1H-2983-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiSYL_STRM5
AccessioniPrimary (citable) accession number: B4SRE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi