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B4SL92

- PUR9_STRM5

UniProt

B4SL92 - PUR9_STRM5

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Smal_3662
Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-3738-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Smal_3662
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000001867: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000096098Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391008.Smal_3662.

Structurei

3D structure databases

ProteinModelPortaliB4SL92.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B4SL92-1 [UniParc]FASTAAdd to Basket

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MTADLLPVRR ALLSVSDKTG LVELATALAA RGVELLSTGG TAKAIRDAGL    50
AVKDVADVTG FPEMMDGRVK TLHPMVHGGL LGRSGLDDAV MAEHGIGAID 100
LLVLNLYPFE SVTAKADCSL ADAVENIDIG GPAMLRSAAK NFARVAVATD 150
PSQYAELLAS LEANNGQLTA ATRFAFSVAA FNRVAQYDAA ISNYLSAVTA 200
TDTAVPVRAE YPAQMNSTFV KVMDLRYGEN PHQSGAFYRD LYPVPGTLAT 250
FQQLQGKELS YNNLADADAA WECVRQFDAP ACVIVKHANP CGVAVGAGNG 300
DAYELAYATD PTSAFGGIIA FNKPLDAATA KVILDRQFVE VLIAPDYEPA 350
ALEYAQKKAN VRVLRIPHGD GLNNFDNKRV GSGLLLQSSD NRGMTRDELK 400
VVSKLAPTDK QFTDLLFAWK VAKFVKSNAI VYAKDNRTIG VGAGQMSRVY 450
SARIAGIKAA DANLVVEGSV MASDAFFPFR DGIDAAAAAG IKAVIQPGGS 500
MRDAEVIAAA DEHGLAMVFT GVRHFRH 527
Length:527
Mass (Da):55,804
Last modified:September 23, 2008 - v1
Checksum:i4A9964CDC6A8CB9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF53361.1.
RefSeqiYP_002030044.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF53361; ACF53361; Smal_3662.
GeneIDi6474542.
KEGGismt:Smal_3662.
PATRICi23712354. VBISteMal40512_3707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF53361.1 .
RefSeqi YP_002030044.1. NC_011071.1.

3D structure databases

ProteinModelPortali B4SL92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391008.Smal_3662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF53361 ; ACF53361 ; Smal_3662 .
GeneIDi 6474542.
KEGGi smt:Smal_3662.
PATRICi 23712354. VBISteMal40512_3707.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SMAL391008:GH1H-3738-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiPUR9_STRM5
AccessioniPrimary (citable) accession number: B4SL92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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