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B4SK42

- PDXA_STRM5

UniProt

B4SK42 - PDXA_STRM5

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei132 – 1321SubstrateUniRule annotation
    Metal bindingi160 – 1601Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi205 – 2051Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi260 – 2601Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei268 – 2681SubstrateUniRule annotation
    Binding sitei277 – 2771SubstrateUniRule annotation
    Binding sitei286 – 2861SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    BioCyciSMAL391008:GH1H-682-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:Smal_0669
    OrganismiStenotrophomonas maltophilia (strain R551-3)
    Taxonomic identifieri391008 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
    ProteomesiUP000001867: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3263264-hydroxythreonine-4-phosphate dehydrogenasePRO_1000128263Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi391008.Smal_0669.

    Structurei

    3D structure databases

    ProteinModelPortaliB4SK42.
    SMRiB4SK42. Positions 1-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221592.
    KOiK00097.
    OMAiDTLFQDK.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4SK42-1 [UniParc]FASTAAdd to Basket

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    MRPELALVPG EPAGIGPELC VRLVQQPRED CRLLAFADPD TLRAAAAALN    50
    LPLQLLPEDA EARVPGDLRV RAVPNAVPSH FGHADPANAG AVIGALLGAG 100
    QACLSGELHG VVTGPVHKAV INEGGIAYSG TTELLADQAG VKVVMMLANH 150
    IVRVALATTH LPLRDVADAI TAPGLEHTLR TVHAALRREF GLAAPRIAVL 200
    GLNPHAGEDG HLGREELDLV IPLLQRLRAE GMDLVGPLPA DTAFLPAKLA 250
    GFDTVLAMYH DQGLPVLKYS GFEQAVNLTL GLPYPRVAVD HGTALDLAGR 300
    GIADPSSLQA ATTLCAQLAR QRTLSA 326
    Length:326
    Mass (Da):33,992
    Last modified:September 23, 2008 - v1
    Checksum:iB830C45424C736C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001111 Genomic DNA. Translation: ACF50374.1.
    RefSeqiWP_012510103.1. NC_011071.1.
    YP_002027057.1. NC_011071.1.

    Genome annotation databases

    EnsemblBacteriaiACF50374; ACF50374; Smal_0669.
    GeneIDi6477697.
    KEGGismt:Smal_0669.
    PATRICi23706176. VBISteMal40512_0680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001111 Genomic DNA. Translation: ACF50374.1 .
    RefSeqi WP_012510103.1. NC_011071.1.
    YP_002027057.1. NC_011071.1.

    3D structure databases

    ProteinModelPortali B4SK42.
    SMRi B4SK42. Positions 1-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391008.Smal_0669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF50374 ; ACF50374 ; Smal_0669 .
    GeneIDi 6477697.
    KEGGi smt:Smal_0669.
    PATRICi 23706176. VBISteMal40512_0680.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221592.
    KOi K00097.
    OMAi DTLFQDK.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci SMAL391008:GH1H-682-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R551-3.

    Entry informationi

    Entry nameiPDXA_STRM5
    AccessioniPrimary (citable) accession number: B4SK42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3