B4SHV9 (BETA_STRM5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	Smal_1832

Organism

Stenotrophomonas maltophilia (strain R551-3) [Complete proteome] [HAMAP]

Taxonomic identifier

391008 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Stenotrophomonas › Stenotrophomonas maltophilia group

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: InterPro
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Choline dehydrogenase HAMAP MF_00750		PRO_1000133338
Regions
	Nucleotide binding	8 – 37	30	FAD Potential
Sites
	Active site	475	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4SHV9 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 724A2DC30444764E	FASTA	560	61,735
	10 20 30 40 50 60 MSTHNEYDYI IIGAGSAGNV LATRLTEDAD VSVLLLEAGG PDYRLDFRTQ MPAALAFPLQ 70 80 90 100 110 120 GKRYNWAYKT DPEPFMNNRR MDCGRGKGLG GSSLINGMCY IRGNAMDYDN WASMPGLEDW 130 140 150 160 170 180 TYLDCLPYFR KAETRDIGPN DYHGGEGPLR VTTPKAGNNE LFAAMVEAGV QAGYPRTDDL 190 200 210 220 230 240 NGYQQEGFGP MDRTVTPKGR RSSTARGYLD LAKPRPNLTI VTHALTDRIL FSGKRAVGVQ 250 260 270 280 290 300 WLHNDQPQRA TARREVLLCG GAIASPQILQ RSGVGPADLL RSLDIDLVHH LPGVGANLQD 310 320 330 340 350 360 HLEMYLQYEC KKPVSLAPAL KLYNQPAIGA EWLFLGTGIG ASNQFEAGGF IRSDTEFDWP 370 380 390 400 410 420 NLQYHFLPVA INYNGSNPIK AHSFQMHVGS MRSPSRGRIH VRSKDPREHP SILFNYMSHD 430 440 450 460 470 480 QDWREFRAAI RITREIFAQP ALAPYSGREI SPGSALQTDA QIDAFVREHA ETAYHPSCSN 490 500 510 520 530 540 KMGHADDPMA VVDGQGRVHG LEGLRIVDAS IMPQVVTGNL NAPTIMIAEK LADVIRGRTP 550 560 LARSTAPYYK ANGAPVRKQG

References

[1]

"Complete sequence of Stenotrophomonas maltophilia R551-3." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Taghavi S., Monchy S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R551-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001111 Genomic DNA. Translation: ACF51536.1.
RefSeq	YP_002028219.1. NC_011071.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B4SHV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6475785.
GenomeReviews	Gene locus Smal_1832 in contig CP001111_GR.
KEGG	smt:Smal_1832.
PATRIC	23708616. VBISteMal40512_1861.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734713.
OMA	RSTAPYY.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_STRM5

Accession

Primary (citable) accession number: B4SHV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program