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B4SHV9

- BETA_STRM5

UniProt

B4SHV9 - BETA_STRM5

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, Smal_1832
Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-1886-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:Smal_1832
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000001867: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_1000133338Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391008.Smal_1832.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4SHV9-1 [UniParc]FASTAAdd to Basket

« Hide

MSTHNEYDYI IIGAGSAGNV LATRLTEDAD VSVLLLEAGG PDYRLDFRTQ    50
MPAALAFPLQ GKRYNWAYKT DPEPFMNNRR MDCGRGKGLG GSSLINGMCY 100
IRGNAMDYDN WASMPGLEDW TYLDCLPYFR KAETRDIGPN DYHGGEGPLR 150
VTTPKAGNNE LFAAMVEAGV QAGYPRTDDL NGYQQEGFGP MDRTVTPKGR 200
RSSTARGYLD LAKPRPNLTI VTHALTDRIL FSGKRAVGVQ WLHNDQPQRA 250
TARREVLLCG GAIASPQILQ RSGVGPADLL RSLDIDLVHH LPGVGANLQD 300
HLEMYLQYEC KKPVSLAPAL KLYNQPAIGA EWLFLGTGIG ASNQFEAGGF 350
IRSDTEFDWP NLQYHFLPVA INYNGSNPIK AHSFQMHVGS MRSPSRGRIH 400
VRSKDPREHP SILFNYMSHD QDWREFRAAI RITREIFAQP ALAPYSGREI 450
SPGSALQTDA QIDAFVREHA ETAYHPSCSN KMGHADDPMA VVDGQGRVHG 500
LEGLRIVDAS IMPQVVTGNL NAPTIMIAEK LADVIRGRTP LARSTAPYYK 550
ANGAPVRKQG 560
Length:560
Mass (Da):61,735
Last modified:September 23, 2008 - v1
Checksum:i724A2DC30444764E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF51536.1.
RefSeqiWP_012510942.1. NC_011071.1.
YP_002028219.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF51536; ACF51536; Smal_1832.
GeneIDi6475785.
KEGGismt:Smal_1832.
PATRICi23708616. VBISteMal40512_1861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF51536.1 .
RefSeqi WP_012510942.1. NC_011071.1.
YP_002028219.1. NC_011071.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 391008.Smal_1832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF51536 ; ACF51536 ; Smal_1832 .
GeneIDi 6475785.
KEGGi smt:Smal_1832.
PATRICi 23708616. VBISteMal40512_1861.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SMAL391008:GH1H-1886-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiBETA_STRM5
AccessioniPrimary (citable) accession number: B4SHV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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