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B4SHI1

- CYOE_STRM5

UniProt

B4SHI1 - CYOE_STRM5

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Protein

Protoheme IX farnesyltransferase

Gene

cyoE

Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. protoheme IX farnesyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. heme O biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-331-MONOMER.
UniPathwayiUPA00834; UER00712.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Heme B farnesyltransferaseUniRule annotation
Heme O synthaseUniRule annotation
Gene namesi
Name:cyoEUniRule annotation
Ordered Locus Names:Smal_0319
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000001867: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Protoheme IX farnesyltransferasePRO_1000096927Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391008.Smal_0319.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalUniRule annotationAdd
BLAST
Transmembranei45 – 6521HelicalUniRule annotationAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei141 – 16121HelicalUniRule annotationAdd
BLAST
Transmembranei172 – 19221HelicalUniRule annotationAdd
BLAST
Transmembranei223 – 24321HelicalUniRule annotationAdd
BLAST
Transmembranei244 – 26421HelicalUniRule annotationAdd
BLAST
Transmembranei277 – 29721HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237291.
KOiK02301.
OMAiIMERTRH.
OrthoDBiEOG6DVJQB.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4SHI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSNYRQYWD LTKPKVVALI VFTALVGMVL AIPGVPSWEQ VRAGVLGFLG
60 70 80 90 100
IWLAASAAAA INQLLDAHID AQMARTSWRP LVVGKVKPWQ VLVFASVLIV
110 120 130 140 150
LSMVILVLWV NLITAVLTFA SLIGYAVIYT VYLKRATSQN IVIGGLAGAM
160 170 180 190 200
PPMLGWAAVT GMQGSSDWAY SSLLVLIIFI WTPPHFWALA IFRREDYAKA
210 220 230 240 250
EIPMLPVTHG VVHTRKQIMV YSVVLALVCL LPYLVGMSGA FYLGGAIVLN
260 270 280 290
AVFLWYAWRM LDPPDELFSM KMFYYSIVYL MALFAFLLVD HWILPWL
Length:297
Mass (Da):33,163
Last modified:September 23, 2008 - v1
Checksum:i00C3B34D22A1F334
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF50024.1.
RefSeqiWP_004138490.1. NC_011071.1.
YP_002026707.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF50024; ACF50024; Smal_0319.
GeneIDi6478115.
KEGGismt:Smal_0319.
PATRICi23705456. VBISteMal40512_0320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001111 Genomic DNA. Translation: ACF50024.1 .
RefSeqi WP_004138490.1. NC_011071.1.
YP_002026707.1. NC_011071.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391008.Smal_0319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF50024 ; ACF50024 ; Smal_0319 .
GeneIDi 6478115.
KEGGi smt:Smal_0319.
PATRICi 23705456. VBISteMal40512_0320.

Phylogenomic databases

eggNOGi COG0109.
HOGENOMi HOG000237291.
KOi K02301.
OMAi IMERTRH.
OrthoDBi EOG6DVJQB.

Enzyme and pathway databases

UniPathwayi UPA00834 ; UER00712 .
BioCyci SMAL391008:GH1H-331-MONOMER.

Family and domain databases

HAMAPi MF_00154. CyoE_CtaB.
InterProi IPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view ]
Pfami PF01040. UbiA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01473. cyoE_ctaB. 1 hit.
PROSITEi PS00943. UBIA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiCYOE_STRM5
AccessioniPrimary (citable) accession number: B4SHI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3