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Protein

Protoheme IX farnesyltransferase

Gene

cyoE

Organism
Stenotrophomonas maltophilia (strain R551-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciSMAL391008:GH1H-331-MONOMER.
UniPathwayiUPA00834; UER00712.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Heme B farnesyltransferaseUniRule annotation
Heme O synthaseUniRule annotation
Gene namesi
Name:cyoEUniRule annotation
Ordered Locus Names:Smal_0319
OrganismiStenotrophomonas maltophilia (strain R551-3)
Taxonomic identifieri391008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000001867 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalUniRule annotationAdd
BLAST
Transmembranei45 – 6521HelicalUniRule annotationAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei141 – 16121HelicalUniRule annotationAdd
BLAST
Transmembranei172 – 19221HelicalUniRule annotationAdd
BLAST
Transmembranei223 – 24321HelicalUniRule annotationAdd
BLAST
Transmembranei244 – 26421HelicalUniRule annotationAdd
BLAST
Transmembranei277 – 29721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Protoheme IX farnesyltransferasePRO_1000096927Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391008.Smal_0319.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237291.
KOiK02301.
OMAiYYEMTKP.
OrthoDBiEOG6DVJQB.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4SHI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSNYRQYWD LTKPKVVALI VFTALVGMVL AIPGVPSWEQ VRAGVLGFLG
60 70 80 90 100
IWLAASAAAA INQLLDAHID AQMARTSWRP LVVGKVKPWQ VLVFASVLIV
110 120 130 140 150
LSMVILVLWV NLITAVLTFA SLIGYAVIYT VYLKRATSQN IVIGGLAGAM
160 170 180 190 200
PPMLGWAAVT GMQGSSDWAY SSLLVLIIFI WTPPHFWALA IFRREDYAKA
210 220 230 240 250
EIPMLPVTHG VVHTRKQIMV YSVVLALVCL LPYLVGMSGA FYLGGAIVLN
260 270 280 290
AVFLWYAWRM LDPPDELFSM KMFYYSIVYL MALFAFLLVD HWILPWL
Length:297
Mass (Da):33,163
Last modified:September 23, 2008 - v1
Checksum:i00C3B34D22A1F334
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001111 Genomic DNA. Translation: ACF50024.1.
RefSeqiWP_004138490.1. NC_011071.1.
YP_002026707.1. NC_011071.1.

Genome annotation databases

EnsemblBacteriaiACF50024; ACF50024; Smal_0319.
KEGGismt:Smal_0319.
PATRICi23705456. VBISteMal40512_0320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001111 Genomic DNA. Translation: ACF50024.1.
RefSeqiWP_004138490.1. NC_011071.1.
YP_002026707.1. NC_011071.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391008.Smal_0319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF50024; ACF50024; Smal_0319.
KEGGismt:Smal_0319.
PATRICi23705456. VBISteMal40512_0320.

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237291.
KOiK02301.
OMAiYYEMTKP.
OrthoDBiEOG6DVJQB.

Enzyme and pathway databases

UniPathwayiUPA00834; UER00712.
BioCyciSMAL391008:GH1H-331-MONOMER.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R551-3.

Entry informationi

Entry nameiCYOE_STRM5
AccessioniPrimary (citable) accession number: B4SHI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: April 1, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.