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Protein

NAD kinase

Gene

nadK

Organism
Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei167NADUniRule annotation1
Binding sitei237NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi137 – 138NADUniRule annotation2
Nucleotide bindingi178 – 183NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPHA324925:G1GCE-2819-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Ppha_2808
OrganismiPelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Taxonomic identifieri324925 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
Proteomesi
  • UP000002724 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208751 – 288NAD kinaseAdd BLAST288

Interactioni

Protein-protein interaction databases

STRINGi324925.Ppha_2808

Structurei

3D structure databases

ProteinModelPortaliB4SGW9
SMRiB4SGW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B4SGW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFAIVVNVT RQNALDLARN LALWLDERKV AYIFESLSAE KLQTDNSAPI
60 70 80 90 100
EELNKHCDAF ISLGGDGTLL FTSHYAVTKP VIGVNVGYLG FLTEFTQAEM
110 120 130 140 150
FTAIERVLNG SNTIHTRSQL DATVLIDNEV QHLRALNDVV IEKGAYPRIP
160 170 180 190 200
TFIIKLDGEL LSSYRADGII IATSTGSTAY SMSAGGPIIA PKSSVFVITP
210 220 230 240 250
ICPHMLTVRP IVISDEKIIE VSVDAPDGSF PLNCDGNLKK MLDPQESITV
260 270 280
RKSTVAINLV ANENRDYCEI LRTKLLWGRE HNFGTIDS
Length:288
Mass (Da):31,654
Last modified:September 23, 2008 - v1
Checksum:i7EF0D942802FD88D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001110 Genomic DNA Translation: ACF44957.1
RefSeqiWP_012509425.1, NC_011060.1

Genome annotation databases

EnsemblBacteriaiACF44957; ACF44957; Ppha_2808
KEGGipph:Ppha_2808

Similar proteinsi

Entry informationi

Entry nameiNADK_PELPB
AccessioniPrimary (citable) accession number: B4SGW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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