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B4SE02

- GCSPA_PELPB

UniProt

B4SE02 - GCSPA_PELPB

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciPPHA324925:GHBF-712-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Ppha_0698
    OrganismiPelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
    Taxonomic identifieri324925 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
    ProteomesiUP000002724: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132484Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi324925.Ppha_0698.

    Structurei

    3D structure databases

    ProteinModelPortaliB4SE02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiYVRKIPG.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4SE02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPFIVNTASE RDEMLKAIGV SSFDDLLVAI PEEIRLKRAL DLFPASDEPQ    50
    VRKLLEGLAS ANKSTADYVS FLGGGAYDHF IPAAIKTITS RSEFYTAYTP 100
    YQAEVSQGTL QAIYEYQSLV CRLYEMDVAN ASMYDGATAL AEAVLMAMNV 150
    TGRSKVVVAG KLHPYNSSVL KTYLEAAGHH AVIQNTLEEG VGSIDALKEL 200
    VGASVAAVVV QQPNFYGSLE DVEAIGAIAH ENGALFVVSA DPLSLGMLAA 250
    PGSYGADIAV GEGQPLGTPQ SFGGPYLGIF TVKQQLVRKI PGRLVGMTKD 300
    RDGEDGFILT LQTREQHIRR EKATSNICSN QALNALQAAI YLSLLGKEGL 350
    QQVATQSAQK AHYLAGKIAA IPGFSLKYKA PFFREFVVET PIPAAAVIER 400
    MLEHKLFAGH DLAVHGETGL LVAVTEKRTK AELDSFVDKL EGITGI 446
    Length:446
    Mass (Da):47,826
    Last modified:September 23, 2008 - v1
    Checksum:iA67ED917C8DB21A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001110 Genomic DNA. Translation: ACF42993.1.
    RefSeqiYP_002017610.1. NC_011060.1.

    Genome annotation databases

    EnsemblBacteriaiACF42993; ACF42993; Ppha_0698.
    GeneIDi6461515.
    KEGGipph:Ppha_0698.
    PATRICi22901832. VBIPelPha134556_0708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001110 Genomic DNA. Translation: ACF42993.1 .
    RefSeqi YP_002017610.1. NC_011060.1.

    3D structure databases

    ProteinModelPortali B4SE02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324925.Ppha_0698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF42993 ; ACF42993 ; Ppha_0698 .
    GeneIDi 6461515.
    KEGGi pph:Ppha_0698.
    PATRICi 22901832. VBIPelPha134556_0708.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi YVRKIPG.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci PPHA324925:GHBF-712-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pelodictyon phaeoclathratiforme BU-1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 5477 / BU-1.

    Entry informationi

    Entry nameiGCSPA_PELPB
    AccessioniPrimary (citable) accession number: B4SE02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3