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B4SDX3

- SYL_PELPB

UniProt

B4SDX3 - SYL_PELPB

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Protein

Leucine--tRNA ligase

Gene
leuS, Ppha_0665
Organism
Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPHA324925:GHBF-679-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ppha_0665
OrganismiPelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Taxonomic identifieri324925 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
ProteomesiUP000002724: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Leucine--tRNA ligaseUniRule annotationPRO_1000091341Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324925.Ppha_0665.

Structurei

3D structure databases

ProteinModelPortaliB4SDX3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B4SDX3-1 [UniParc]FASTAAdd to Basket

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MRYEFSKTEA KWQAWWKEQN TFKTGDDADK PKYYVLDMFP YPSGTGLHVG    50
HLEGYTASDI TARYKRSCGY NVLHPMGWDA FGLPAEQFAI KTGTHPKTTT 100
EENIRNFKGT LQAMGFSYDW SREINTTDPH YFKWTQWIFL KLYERGLAYM 150
SEVDVNWCEE LKTVLANEEV DEKIADGYTV VRRPLRQWVL KITAYADRLL 200
ADLDELNWPE NVKQMQRNWI GRSEGVEIDF ELRCHNKKLR VYTTRPDTLF 250
GATYLVISPE HPLAEKLATA QQLVEVKNYI SKAKLKTELE RTGLQKEKTG 300
VFTGSYAINP ATGEPLPVWI SDFVLISYGT GAIMSVPAHD SRDWEFAKQY 350
NLPIIEVIQS PHDVQERVFE EKESICVNSA NNEITLNGLP FCEAFERMAS 400
WLETKKAGER KVNYKLRDWI FSRQRYWGEP IPIKHYHDGT LRLETALPLV 450
LPEVEAYHPS STGESPLANI PHWLYGSDEH GSFRRETNTM PQWAGSCWYY 500
LRFIDPENQE KLVDPEKERY WMNVDLYIGG AEHAVLHLLY ARFWHKVLFD 550
LGVVSSREPF KKLFNQGMIL GEDNEKMSKS RGNVIPADHV LERYGADAVR 600
LYEMFLGPLE QVKPWNTNGI EGISRFLSKV WRLVYGEHEE SATLLSEEAM 650
PEELLRRMHK SIKKVGEDTE QLKFNTAISE MMVFVNELQK SGCKNRSAIE 700
TLLVLLSPYA PHITEELWES IGHNYSISQA PFPSFDPKLV EESILTIAVQ 750
INGKLRGTFL APAKSPKELL LQEAKKTESV FKFLDGQTIL REIVVVDKLV 800
NFVVKKE 807
Length:807
Mass (Da):93,181
Last modified:September 23, 2008 - v1
Checksum:i37E6878C5B71A15B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001110 Genomic DNA. Translation: ACF42964.1.
RefSeqiYP_002017581.1. NC_011060.1.

Genome annotation databases

EnsemblBacteriaiACF42964; ACF42964; Ppha_0665.
GeneIDi6461585.
KEGGipph:Ppha_0665.
PATRICi22901764. VBIPelPha134556_0674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001110 Genomic DNA. Translation: ACF42964.1 .
RefSeqi YP_002017581.1. NC_011060.1.

3D structure databases

ProteinModelPortali B4SDX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324925.Ppha_0665.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF42964 ; ACF42964 ; Ppha_0665 .
GeneIDi 6461585.
KEGGi pph:Ppha_0665.
PATRICi 22901764. VBIPelPha134556_0674.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PPHA324925:GHBF-679-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pelodictyon phaeoclathratiforme BU-1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5477 / BU-1.

Entry informationi

Entry nameiSYL_PELPB
AccessioniPrimary (citable) accession number: B4SDX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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